替来他明和唑拉西泮复合麻醉对比格犬生理及血气指标的影响  

Effect on physiological and blood gas indicators of beagles by combined anesthesia with tiletamine and zolazepam

作　　者：鲁永玲[1] 范仕郡[1] 陈倩[1] 郑江[1] 

机构地区：[1]第三军医大学西南医院中心实验室,重庆400038

出　　处：《局解手术学杂志》2017年第2期86-89,共4页Journal of Regional Anatomy and Operative Surgery

基　　金：国家自然科学基金(81372089)

摘　　要：目的观察比格犬经替来他明和唑拉西泮复合麻醉前后的心率、体温、血压以及血气的变化规律,为应用比格犬进行研究提供有关麻醉剂影响动物检测指标的实验数据。方法实验选用替来他明和唑拉西泮(1∶1)稀释后肌肉注射(10 mg/kg)对比格犬行全身麻醉,麻醉前、后分别采集动脉血,通过血气分析仪检测血气指标,同时应用大动物心电监护仪测定比格犬麻醉前后生理指标(心率、血压、体温)。结果比格犬经替来他明和唑拉西复合麻醉后,动脉血气指标中p H显著降低,差异具有极显著性统计学意义(P<0.01);PCO2显著升高,而PO2显著下降,差异具有统计学意义(P<0.05);Lac和HCO3-无明显变化,表现为明显的呼吸性酸中毒。生理指标中血压变化无统计学意义。心率明显升高,体温明显下降,差异均具有极显著统计学意义(P<0.01)。上述指标在性别间比较差异均无统计学意义。结论采用替来他明和唑拉西泮复合麻醉比格犬,可引发呼吸抑制和气道堵塞等现象,导致呼吸性酸中毒的发生,同时还可引起心率升高和低体温的发生。在实验过程中要注意保暖和保持呼吸畅通,在进行动物指标差异比较时要考虑麻醉剂的影响。Objective To study the physiological indicators and arterial blood gas values, and create a reliable data for researchers using beagle dogs. Methods Beagle were sampled before and after Zoletil anesthesia （ 10 mg/kg） via intramuscular injection. Then aterial blood gas was detected by blood gas analyzer. Then the physiological indicators, including heart rate, blood pressure and body temperature were measured via large animal ECG. Results For blood gas values, the pH value decreased significandy （ P 〈 0.01 ）. pCO2 increased signifi- candy and pO2 decreased significantly, the differences were significantly （ P 〈 0.05 ）. In contrast, levels of Lac and HCO3^- remained unal- tered,indicating a typical respiratory acidosis. For physiological indicators, blood pressure increased slightly, but not significant. The heart rate increased significantly （P 〈 O. 01 ） and body temperature decreased significantly （P 〈 0.01 ）. There was no difference between sexes. Con- clusion Zoletil anesthesia causes respiratory arrest and respiratory congestion,which further induced respiratory acidosis, Meanwhile, anes- thesia also results in elevated heart rhythm and lower body temperature. These data indicate that warming and airway clear are necessary dur- ing anesthesia in Beagles. Moreover,it should be considered about the effects of anaesthetics when comparing differents in animals before and after treatment.

关 键 词：比格犬 替来他明 唑拉西泮 复合麻醉 生理指标 血气 

分 类 号：R246.2[医药卫生—针灸推拿学] Q4-3[医药卫生—中医临床基础]