磁共振波谱定量检测孤独症患儿基底节区代谢特征  

Quantitative ~1H-MRS study of metabolite characteristics of autism spectrum disorders in basal ganglia regions

作　　者：代海洋[1] 黎倩仪 李胜开[1] 肖叶玉[3] 吴仁华[3] 

机构地区：[1]惠州市中心人民医院放射科,惠州516001 [2]东莞市第八人民医院放射科,东莞523326 [3]汕头大学医学院第二附属医院医学影像科,汕头515041

出　　处：《磁共振成像》2017年第1期8-12,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：广东省医学科学技术研究基金项目(编号:A2015536);惠州市中心人民医院重点扶持项目(编号:2015009)~~

摘　　要：目的利用磁共振波谱及LCModel后处理软件定量检测孤独症患儿双侧基底节区代谢物特征并与正常发育儿童进行对比。材料与方法对符合诊断标准的13例孤独症患儿和14例正常发育儿童基底节区进行磁共振波谱采集,利用LCModel软件对波谱数据进行后处理分析。结果相对于正常发育儿童,孤独症患儿双侧基底节区Glx、Glu和Cho的绝对浓度以及Glx/Cr、Glu/Cr和右侧基底节区Cho/Cr比值增高且差异有统计学意义。孤独症患儿双侧基底节区NAA绝对浓度较正常发育儿童降低但差异无统计学意义,NAA/Cr较正常发育儿童减低且差异有统计学意义。孤独症患儿双侧基底节区MI绝对浓度和MI/Cr值较正常发育儿童增高,但差异无统计学意义。结论孤独症患儿基底节区存在代谢异常,基底节区Glx、Glu和Cho浓度的增高以及NAA/Cr的降低可能与孤独症的发病存在一定关系。Objective： To investigate the metabolite changes in the basal ganglia regions of autistic children using 1H-MRS and LCModel. Materials and Methods： Thirteen autistic children and 14 normal developed children were enrolled in the study. MRS data were acquired in the bilateral basal regions and processed by LCModel software. Results： Compared with normal developed children, the absolute concentration of Glx, Glu and Cho in bilateral basal ganglia regions were increased with statistical significance. The ratio of Glx/Cr, Glu/Cr in bilateral basal ganglia and Cho/Cr in the right basal ganglia of autistic children was increased with statistical significance. The absolute concentration of NAA in bilateral basal ganglia of autistic children was decreased without statistical significance, while the ratio of NAA/Cr in bilateral basal ganglia was decreased with statistical significance. The absolute concentration of MI and the ratio of MI/Cr were increased in bilateral basal ganglia in autistic children without statistical significance. Conclusions： Abnormal metabolite alternation was found in the basal ganglia regions of autistic children. The increase of Glx, Glu, Cho and decrease of NAA/Cr may relate to the pathogenesis of autism.

关 键 词：自闭症谱系障碍 磁共振波谱学 代谢 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749[医药卫生—诊断学]