类风湿性关节炎合并核抗体阳性的临床意义  

The clinical significance of rheumatoid arthritis merger antinuclear antibody positive

作　　者：李亚波[1] 周芳[1] 邹映东[1] 豆银芯[1] 林云[1] LI Yabo ZHOU Fang ZOU Yingdong DOU Yinxin L IN Yun(Department of Clinical Laboratory ,Yunnan Provincial Hospital of Traditional Chinese Medicine , Kunming , Yunnan 650021 ,China)

机构地区：[1]云南省中医医院检验科,昆明650021

出　　处：《国际检验医学杂志》2017年第2期184-186,共3页International Journal of Laboratory Medicine

摘　　要：目的了解类风湿性关节炎(RA)合并核抗体(抗-ANA)阳性的荧光模式和靶抗原分布情况,以及抗-ANA在RA中的影响。方法收集2014-2015年该院风湿科860例RA患者的类风湿因子(RF)、环瓜氨酸抗体(抗-CCP)及抗-ANA等资料,以抗-ANA情况分为抗-ANA阳性组与抗-ANA阴性组,分析2组RA患者RF、抗-CCP血清水平的差异;统计RA合并抗-ANA阳性的荧光模式和靶抗原、抗体分布情况。结果 860例RA合并抗-ANA阳性率37.6%,RA合并抗-ANA阳性的荧光模式以核颗粒型,抗-SSA阳性为主(21.7%);抗-ANA阳性组与抗-ANA阴性组RF和抗-CCP血清水平比较,差异均有统计学意义(P<0.05)。结论 RA合并抗-ANA阳性可表现出不同的荧光模式和靶抗原,以核颗粒型,抗-SSA阳性为主。抗-ANA阳性组与抗-ANA阴性组RA患者在关节炎性反应严重程度以及骨质破坏程度方面存在差异,抗-ANA阳性对RA疾病的进展具有一定的促进作用。Objective To understand the fluorescence pattern of antinuclear antibody（ANA）and the distribution of target antigen and ANA′s impact on rheumatoid arthritis（RA）RA.Methods The data of rheumatoid factor（RF）and anti-cyclic citrullinated peptide antibodies（anti-CCP antibodies）and ANA of 860 RA patients during 2014-2015 were collected and divided into 2groups according to the ANA levels.The differences of RF and anti-CCP antibodies level between 2groups were analyzed.Analyzed the fluorescence pattern of RA merger ANA and the distribution of target antigen by statistical.Results Of the 860 RA patients,the positive rate of ANA was 37.6%,the major fluorescence pattern of RA merger ANA was speckled pattern,anti SSA positive rate was 21.7%.The RF and anti-CCP antibodies level had statistical difference between ANA positive group and ANA negative group（P〈0.05）.Conclusion RA merger ANA positive can show different fluorescence patterns and target antigen,the speckled pattern and anti-SSA positive are the main pattern.The severity of arthritis symptoms and the degree of bone destruction between ANA positive group and ANA negative group were difference.Anti-ANA positive has a certain promoting effect on the progression of RA disease.

关 键 词：类风湿性关节炎 抗核抗体 类风湿因子 环瓜氨酸抗体 

分 类 号：R593.22[医药卫生—内科学]