妊娠期糖尿病患者肠道菌群及炎症因子的变化  

Changes of intestinal flora and inflammatory factors in patients with gestational diabetes mellitus

作　　者：陈青华[1] 齐伟翠[1] 

机构地区：[1]丽水市中医院检验科,浙江丽水323000

出　　处：《中国微生态学杂志》2016年第12期1453-1455,共3页Chinese Journal of Microecology

摘　　要：目的探讨妊娠期糖尿病患者肠道菌群及炎症因子的变化。方法选择38例在丽水市中医院就诊的妊娠期糖尿病患者为观察组,选择同期就诊的正常孕妇50例为对照组,两组患者均检测肠道双歧杆菌、乳酸杆菌、拟杆菌含量,比较菌群失调发生率,同时检测并比较炎症因子IL-2、IL-6水平,探讨两组患者的肠道菌群及炎症因子的差异。结果观察组双歧杆菌、乳酸杆菌、拟杆菌的数量均少于对照组（t_双=2.41,t_乳=2.27,t_拟=2.14,P均〈0.05）;观察组肠道菌群失调发生率高于对照组（χ~2=6.29,P〈0.05）;观察组IL-2水平较对照组低,IL-6水平较对照组高（t_（IL-2）=3.74,t_（IL-6）=3.21,P均〈0.01）。结论妊娠期糖尿病患者容易出现肠道菌群失调,影响患者的免疫功能,应及早进行干预治疗。Objective To discuss the changes of intestinal flora and inflammatory lactors m panents with gesrational diabetes mellitus （GDM） . Methods Thirty-eight patients with GDM, who were given the medical treatment in our hospital, were selected as the observation group, while 50 healthy pregnant women were selected at the same time as the control group. Both groups were detected for bifidobacteria, lactobacilli and bacteroides, and the occurrence rates of dysbacteriosis were compared. The levels of inflammatory fac- tors IL-2 and IL-6 were detected and compared, and the differences of intestinal flora and inflammatory factors in two groups were discussed. Results The quantities of bifidobacteria, lactobacilli and bacteroides of patients in observation group were less than those in control group （P〈0.05） . The occurrence rate of dysbacteriosis in observation group was higher than that in control group （P〈0.05） . The IL-2 level of patients in observation group was lower than that in control group, while IL-6 level was higher than that in control group （P〈0.01） . Conclusion Dysbacteriosis frequently occur in patients with GDM, which may influence the immune function and should be given early intervention.

关 键 词：妊娠期糖尿病 肠道菌群 炎症因子 

分 类 号：R378[医药卫生—病原生物学]