高龄女性的卵子和胚胎质量  

Quality of oocytes and embryos of elder women

作　　者：李梅[1] LI Mei(Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory of Reproductive Endocrinology （Shandong University）, Ministry of Educatio Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan 250001, Shandong, China)

机构地区：[1]山东大学附属生殖医院国家辅助生殖与优生工程技术研究中心生殖内分泌教育部重点实验室(山东大学)山东省生殖医学重点实验室,山东济南250001

出　　处：《山东大学学报（医学版）》2017年第1期16-21,共6页Journal of Shandong University:Health Sciences

基　　金：国家自然科学基金重点项目(81430029);国家自然科学基金(81401266);卫生公益性行业科研专项(201402004);山东大学基本科研业务费专项资金(2015QY004-19);山东省自然科学基金(ZR2013HQ053)

摘　　要：高龄女性卵巢储备不足、生育功能低下一直是生殖医学的难题,卵子和胚胎质量的下降是导致高龄女性妊娠率低、流产率高的主要原因。辅助生殖技术可通过促排卵、改进培养方案、胚胎植入前遗传学筛查等技术,以提高高龄女性每周期获得优质卵子和胚胎的机会,从而提高妊娠率。但高龄女性的卵子和胚胎质量难以逆转,年龄因素导致的卵巢功能低下并非目前的医疗手段能够解决,女性应该避免高龄生育。Poor ovarian reserve and lowfertility in elder women have been troubling both the patients and doctors. Lowoocyte and embryo quality is the primary cause for lowpregnancy rate and high abortion rate. Assisted reproductive technology（ ART） can help ovarian stimulation,culture protocol modification and preimplantation genetic screening（ PGS）,which are conducive to obtaining healthy oocytes and embryos per cycle. However,ART is unable to increase the quality of oocytes and embryos derived from elder women. So far,there is no solution available to improve the lowovary function in elder women. Therefore,elder women should take it seriously before they decide to conceive.

关 键 词：高龄 卵子 胚胎 妊娠 辅助生殖技术 

分 类 号：R711.6[医药卫生—妇产科学]