AFP阳性与阴性小肝癌的超声造影定量分析参数对比研究  

A Comparative Study about Contrast-enhanced Ultrasound Imaging Quantitative Parameters of AFP Positive Small Hepatocellular Carcinoma versus AFP Negative Small Hepatocellular Carcinoma

作　　者：李红学[1] 刘军杰[1] 丁战玲[1] 赵盛发[1] 李航[1] 

机构地区：[1]广西医科大学附属肿瘤医院超声科,南宁530021

出　　处：《医学研究杂志》2017年第1期74-76,共3页Journal of Medical Research

基　　金：广西壮族自治区科学研究与技术开发计划项目(桂科攻14124003-4);广西壮族自治区卫生厅科研基金资助项目(Z2015572);广西壮族自治区肝癌诊疗工程技术研究中心(2014GCZX20)

摘　　要：目的分析AFP阳性与阴性小肝癌患者的超声造影特征,并对超声造影定量分析参数进行对比研究。方法回顾性分析60例经病理证实的小肝癌患者的超声造影表现,并应用TIC软件分析AFP阳性与阴性小肝癌与周围肝实质的造影剂到达时间、达峰时间、峰值强度、流出时间和和曲线下面积。结果 60例小肝癌患者超声造影均表现为"快进快出"的特征,灌注曲线呈"快上快下"的形态。AFP阳性与阴性小肝癌间到达时间、达峰时间和峰值强度比较,差异无统计学意义(P>0.05)。AFP阳性与阴性小肝癌间流出时间和和曲线下面积比较,差异有统计学意义(P<0.05)。结论 AFP阳性与阴性小肝癌超声造影均表现为"快进快出"的特征,而AFP阳性小肝癌"快进快出"的特征更为明显。Objective To study on the performance characteristic of contrast- enhanced ultrasound （CEUS） in AFP positive small hepatocelluiar carcinoma （SHCC） and AFP negative small hepatocellular carcinoma, and to analysis their quantitative analysis parame- ters. Methods A total of 60 SHCC patients confirmed by pathology were recruited, and the characteristic of CEUS were analyzed. The arrival time （AT） , time to peak （TTP）, peak intensity （PI） , washout time （WT） and area under the curve （AUC） of contrast agents in SHCC and surrounding liver tissue of AFP positive SHCC and AFP negative SHCC were analyzed by time - intensity curve（TIC）. Results The CEUS performance of 60 patients with SHCC was ＂fast - in and fast - out＂, and the perfusion curve showed ＂fast - up and fast - down＂. The differences of AT, TTP and PI between AFP positive SHCC and AFP negative SHCC were not statistically significant. The differences of WT and ARU between AFP positive SHCC and AFP negative SHC were statistically significant. Conclusion The CEUS performance of AFP positive SHCC and AFP negative SHCC was ＂fast - in and fast - out＂. This feature was more obvious in the AFP pos- itive SHCC.

关 键 词：小肝癌 超声造影 定量分析参数 

分 类 号：R445[医药卫生—影像医学与核医学]