间充质-上皮转化的生物学作用及其影响因素  

Biological functions and influential factors of mesenchymal-epithelial transition

作　　者：和鹏飞 魏凯[1] 谢院生[1] He Pengfei Wei Kai Xie Yuansheng(Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology , State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing 100853, China)

机构地区：[1]解放军总医院肾脏病科、解放军肾脏病研究所、肾脏疾病国家重点实验室、国家慢性肾病临床医学研究中心,北京100853

出　　处：《中华肾病研究电子杂志》2016年第6期281-284,共4页Chinese Journal of Kidney Disease Investigation（Electronic Edition）

基　　金：北京市自然科学基金项目(7152138);国家自然科学基金项目(81473531)

摘　　要：细胞可塑性是机体多种生物学过程的基础。其中,上皮表型和间充质细胞表型的相互转化是不可忽视的生物学过程。间充质细胞向上皮细胞转化在胚胎发育早期阶段就已开始,并且参与了肾脏等多个器官的形成。此外,间充质上皮转化还参与了机体组织的损伤修复以及肿瘤的发生发展过程。研究表明,多种因素可以促进间充质-上皮转化进程,可能成为促进组织损伤修复和抑制肿瘤生长的治疗靶点。Cellular plasticity is the basis of many biological processes in the body. The transition between epithelial phenotype and mesenchymal phenotype is of great importance. Mesenchymal-epithelial transition（ MET） begins at the early stage of embryo development and is involved in the organogenesis of kidney and other organs. In addition,MET is also involved in the repair of injury and the development of carcinomas. It has been reported that many factors could affect MET,which might become targets for promoting the repair of tissue injuries and inhibiting the development of carcinomas.

关 键 词：上皮-间充质转化 间充质-上皮转化 损伤修复 肿瘤进展 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]