复方甘草酸苷注射液辅助治疗过敏性紫癜临床观察及其对Th1/Th2型细胞因子水平的影响  

Effect of Compound Glycyrrhizin on Th1/Th2 Cytokines in Children with Henoch-Schonlein Purpura

作　　者：牛文忠[1] 张雪松[1] 丁显春[1] NIU Wen-zhong ZHANG Xue-song DING Xian-chun(Department of Pediatrics, Nanyang Central Hospital, Nanyang 473000, Chin)

机构地区：[1]南阳市中心医院儿科,河南南阳473000

出　　处：《中国皮肤性病学杂志》2017年第2期144-146,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的评价复方甘草酸苷(GL)辅助治疗过敏性紫癜(HSP)的临床疗效和其对患儿血清Th1/Th2型细胞因子水平的影响,探讨其发病机制。方法将入选的90例HSP患儿随机分为两组,各45例。全部患儿予常规治疗,治疗组患儿同时予GL静滴,疗程均为7~10天。酶联免疫吸附法(ELISA)检测入选患儿和健康对照组儿童血清干扰素-γ(IFN-γ)和白介素-10(IL-10)水平。结果治疗前,三组入选者血清IFN-γ水平和两组患儿血清IL-10水平差异均无统计学意义(P均>0.05),仅健康对照组儿童血清IL-10水平明显低于其他两组患儿血清IL-10水平。治疗结束时,两组患儿血清IFN-γ水平分别与其治疗前比较均无明显改变,且该两组患儿血清IFN-γ水平差异也均无统计学意义(P均>0.05);但是两组患儿治疗后血清IL-10水平明显低于其治疗前,且治疗组患儿血清IL-10水平明显低于对照组患儿血清IL-10水平,治疗组有效率(99.33%)明显高于对照组(77.78%),差异均有统计学意义(P<均0.05)。结论 GL治疗HSP疗效确切,其可能通过抑制IL-10分泌,使Th1/Th2趋向平衡而发挥治疗作用。Objective To evaluate the effect of Compound Glycrrrhizin（GL） therapy on Th1/Th2 cytokines in children with Henoch-Schonlein pnrpura（HSP）. Methods Ninety children with HSP were randomly divided into two groups, 45 cases each. All children received conventional treatment. Children in treatment group were intravenously administered with GL for 7 - 10 days. Levels of interferon-γ（IFN-γ） and interleukin-10 （IL-10） in sera from patients and healthy controls were detected by using enzyme-linked immunosorbent assay （ELISA）. Results Before treatment, the differences in the level of IFN-γ in the three groups and IL-10 in two groups were not statistically significant （ all P 〉 0. 05 ）, however, the level of IL - 10 in healthy control was significantly lower than that in other two groups. At the endpoint of treatment, there was no significant difference in the level of IFN-γ between two treatment groups and controls （ all P 〉 0. 05 ）. Interestingly, the level of IL-10 in two groups was significantly lower than that in pretreatment period; the level of IL-10 in treatment group was also significantly lower than control group, the overall response rate was 93.33% in treatment group and 77.8% in control group, respectively, which demonstrated statistically significant difference （ all P 〈 0. 05 ）. Conclusion GL therapy might be effective on HSP through inhibition of the secretion of IL-10 and maintenance of a balanced Th1/Th2 cytokine profile.

关 键 词：过敏性紫癜 复方甘草酸苷 TH1/TH2 干扰素-γ 白介素-10 

分 类 号：R554.6[医药卫生—血液循环系统疾病]