白三烯与动脉粥样硬化关系的研究新进展  

Research Progress in Relationship between Leukotrienes and Arteriosclerosis

作　　者：蔡丽娟[1] 杨美雯 洪芬芳[3] 况晓东[4] 杨建华[5] 杨树龙[5] 

机构地区：[1]南昌大学第四临床医学院,南昌330003 [2]南昌大学抚州医学院,江西抚州344000 [3]南昌大学医学实验教学部,南昌330006 [4]南昌大学基础医学院病理学教研室,南昌330006 [5]南昌大学基础医学院生理学教研室,南昌330006

出　　处：《南昌大学学报（医学版）》2016年第6期80-84,共5页Journal of Nanchang University：Medical Sciences

基　　金：国家自然科学基金(No.81660751,81660151,81260504);江西省科技厅科技计划项目(No 20161BBG70067);南昌大学教学改革研究课题(NCUJGLX-14-1-111);南昌大学创新学分科研训练项目(No.2015-349,351,569);南昌大学创新创业科研训练项目(No.301 295)

摘　　要：白三烯(Leukotrienes,LTs)是由炎性细胞产生具有高度生物活性的炎性介质。动脉粥样硬化(atherosclerosis,AS)及其并发症是当今世界导致死亡的最常见的病因之一。炎症反应是AS的一个关键性致病机制。LTs能促使单核细胞趋向血管内皮细胞,并发生黏附和迁移,最后转化为巨噬细胞与泡沫细胞,进一步使血管平滑肌细胞增殖、激活淋巴细胞以及刺激冠状动脉收缩等,参与AS的病程。LTs也通过与其受体结合发挥趋化作用,在启动内皮炎症反应、影响斑块稳定性、导致血管重构等方面发挥重要作用。Leukotrienes（LTs）are a kind of important inflammatory mediators with high biological activity produced by inflammatory cells.Atherosclerosis（AS）and its complications are one of the most primary causes of death in the world today.Inflammatory response is considered as a key pathogenic mechanism of AS.Recent studies suggest that LTs participate in the occurrence and development of AS by prompting the adhesion and migration of mononuclear cells to endothelial cells and their transformation to macrophages and foam cells,accelerating the proliferation of vascular smooth muscle cells,activating the lymphocytes,and stimulating the contraction of coronary arteries.LTs can also trigger endothelial inflammatory response,change plaque stability and cause vascular remodeling by combining with their receptors.

关 键 词：白三烯 动脉粥样硬化 5-脂氧合酶 炎症 

分 类 号：R541.4[医药卫生—心血管疾病]