盐酸齐拉西酮大鼠在体肠吸收动力学  

Kinetics of in situ intestinal absorption of ziprasidone hydrochloric acid in rats

作　　者：苗燕飞[1] 陈国广[2] 任丽莉[2] 欧阳平凯[1] 

机构地区：[1]南京工业大学生物与制药工程学院,江苏南京211800 [2]南京工业大学药学院,江苏南京211800

出　　处：《南京工业大学学报（自然科学版）》2017年第1期133-136,共4页Journal of Nanjing Tech University(Natural Science Edition)

基　　金：江苏省科技厅前瞻性联合研究(BY2015005-11)

摘　　要：建立灌流液中盐酸齐拉西酮含量的高效液相色谱法(HPLC),研究盐酸齐拉西酮的SD大鼠在体肠吸收动力学。采用大鼠在体单向肠灌流模型,研究盐酸齐拉西酮在不同肠段的吸收特性以及不同药物浓度和胆汁分泌对盐酸齐拉西酮吸收的影响。结果表明:盐酸齐拉西酮在大鼠全肠段均有吸收,其中十二指肠吸收大于结肠,吸收速率常数(K)分别为(4.69±0.33)和(2.61±0.37)h-1。盐酸齐拉西酮在不结扎胆管的十二指肠吸收速率大于结扎胆管。随着肠灌流液中盐酸齐拉西酮浓度的升高,吸收速率常数呈上升趋势。盐酸齐拉西酮在体的吸收方式为被动扩散。The kinetics of in situ intestinal absorption of ziprasidone in SD rats was studied from analysis the content of ziprasidone in recirculation fluid with a high performance liquid chromatography （HPLC ）.The in situ single-way perfusion rat model was used for the absorption behaviors of ziprasidone in each intestinal segment of rats.The effect of drug concentration and the bile salt on the intestinal absorption were also investigated. Results showed that ziprasidone was absorbed in the total intestinal with the absorption rate constant （ K ） of duodenum of （4. 69 ± 0？ 33） and （2. 61 ± 0？ 37） h-1 in colon. The absorption rate constant in duodenum was higher with free access to bile salt compared with the bile duct ligation.With the increase of the concentration of ziprasidone,the absorption rate constant was increased.The absorption of ziprasidone occurred via the simple diffusion.

关 键 词：齐拉西酮 在体肠灌流 高效液相色谱 

分 类 号：R969.1[医药卫生—药理学]