DABCO-催化合成呋喃并[3,2-c]香豆素类化合物  

DABCO-catalyzed synthesis of furo[3,2-c]coumarin derivatives

作　　者：王道林[1] 马健[1] 李林娟[1] 杨阳[1] 石晓策 

机构地区：[1]辽宁省功能化合物合成与应用重点实验室,渤海大学化学化工学院,辽宁锦州121003

出　　处：《化学研究与应用》2017年第1期84-88,共5页Chemical Research and Application

摘　　要：在1,4-二氮杂二环[2,2,2]辛烷(DABCO)作用下,以水为反应介质,通过3-溴乙酰基-4-羟基香豆素与芳香醛的亲核取代、分子内环化及消除的串联反应,有效合成了新型呋喃并[3,2-c]香豆素类化合物。产物结构经熔点、红外光谱、核磁共振谱等予以确认。A simple and efficient method for the synthesis of novel furo[3,2-c]coumarin derivatives had been developed by the reaction of 3-bromoacetyl-4-hydroxycoumarin with aryl aldehydes in the presence of1,4-diazabicyclo[2. 2. 2]octane; triethylene-diamine（ DABCO） underwent a domino nucleophilic / cyclization / elimination process in H2 O.All of above compounds had been confirmed by NMR,IR,MS spectra and elemental analysis.

关 键 词：香豆素 3-溴乙酰基-4-羟基香豆素 呋喃并[3 2-c]香豆素 DABCO 串联反应 

分 类 号：O626[理学—有机化学]