4-取代-2,4-二羰基丁酸酯的不对称转移氢化反应研究及应用  

Asymmetric transfer hydrogenation of γ-aryl α,γ-dioxobutyric acid esters and its application

作　　者：张瑞征 莫元昭 沈卫所[1] 王全军[2] 

机构地区：[1]西安交通大学附属中学,陕西西安710043 [2]第四军医大学药学系,陕西西安710032

出　　处：《化学研究与应用》2017年第1期132-136,共5页Chemical Research and Application

基　　金：陕西省自然科学基金项目(2016JM8070)资助;国家自然科学基金项目(21102175)资助

摘　　要：在(R,R)-RuCl(Fsdpen)(p-cymene)催化下进行了4-芳基-2,4-二羰基丁酸酯的不对称氢转移反应研究。考察了溶剂和温度对反应的影响;并以DMF为溶剂在0℃时进行了7种4-芳基-2,4-二羰基丁酸酯的不对称转移氢化(ATH)反应,得到高达85%产率和96%ee的反应产物;同时探索了(2R,4S)-α-羟基-γ-苯基-丁内酯的不对称合成。The probe of the asymmetric transfer hydrogenation（ ATH） of a series of γ-aryl-α,γ-dioxo-butyric acid esters had been conducted with（ R,R）-Ru Cl（ Fsdpen）（ p-cymene） as catalyst.The reaction conditions were optimized and seven substrates＇ ATH proceeded smoothly.Up to 85%chemical yields and 96%ee were obtained.Simultaneously,the synthesis of a trans-2,4-disubstituted butyrolactone could also be achieved with a yield of 45%.

关 键 词：不对称氢转移反应 (R R)-Ru Cl(Fsdpen)(p-cymene) 4-芳基-2 4-二羰基丁酸酯 Γ-丁内酯 

分 类 号：O626.23[理学—有机化学]