7-氨基-6-芳基偶氮-5-羟基吡唑[1,5-a]并嘧啶-3-甲酸乙酯的合成  

Synthesis of 7-amino-6-arylazo-5-hydroxylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

作　　者：于姝燕[1] 成日青[1] 鲁源[1] 成学丽[1] 

机构地区：[1]内蒙古医科大学药学院,内蒙古呼和浩特010110

出　　处：《化学研究与应用》2017年第1期142-146,共5页Chemical Research and Application

基　　金：内蒙古医科大学高等教育教学改革项目(NYJXGG2016050)资助

摘　　要：以氰乙酸乙酯和原甲酸三乙酯为原料,经过缩合、肼解、关环、重氮化及偶合等反应合成了13个新型的嘌呤类似物7-氨基-6-芳基偶氮-5-羟基吡唑[1,5-a]并嘧啶-3-甲酸乙酯(5a-5m)。通过IR、~1H NMR、MS和元素分析确定了所得化合物的结构。In the basis of ethyl cyanoacetate and triethyl orthoformate,13 new purine analogues were synthesized by condensation,nitrile hydrolysis,cyclization,diazotization and coupling reaction. They were 7-amino-6-arylazo-5-hydroxypyrazolo[1,5-a]pyrimidine-3-carboxylate derivatives（ 5a-5m）. The structures of target compounds were characterized by IR,and -1H-NMR,MS and elemental analysis.

关 键 词：嘌呤类似物 7-氨基-6-芳基偶氮-5-羟基吡唑[1 5-a]并嘧啶-3-甲酸乙酯 合成 

分 类 号：O626[理学—有机化学]