艾司洛尔治疗不稳定型心绞痛疗效及相关因素  

Curative effects and related factors of esmolol in treatment of unstable angina pectoris

作　　者：杨娜[1] 刘冰[1] 梁晗[1] 罗磊[1] 肖婷[1] 

机构地区：[1]商洛市中心医院心内三科,陕西商洛726200

出　　处：《西南国防医药》2017年第1期14-17,共4页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的探讨艾司洛尔联合地尔硫卓治疗不稳定型心绞痛疗效及近期预后影响因素。方法选取2013年2月~2015年7月医院收治的不稳定型心绞痛患者126例,随机分为观察组(艾司洛尔+地尔硫卓)和对照组(地尔硫卓),各63例,比较两组的临床疗效、治疗前后心绞痛情况,分析影响预后的相关因素。结果观察组总有效率为91.91%,对照组为73.02%,差异具有统计学意义(P<0.05)。治疗前,两组的心绞痛发作次数、持续时间、血浆黏度及纤维蛋白原水平无统计学差异(P>0.05);治疗后,两组上述指标均明显降低,且观察组变化幅度更大(P<0.05)。多因素Logistic回归分析结果显示,Braunwald分级、发作次数、发作持续时间、CK-MB、c Tn I是不稳定型心绞痛患者近期预后的独立影响因素(P<0.05)。结论艾司洛尔联合地尔硫卓治疗不稳定型心绞痛疗效显著,能够有效缓解临床症状;Braunwald分级、发作次数、发作持续时间、CK-MB、c Tn I是不稳定型心绞痛患者近期预后的独立影响因素。Obje ctive To explore the curative effects and prognostic influencing factors of esmolol combined with diltiazem in the treatment of unstable angina pectoris. Methods A total of 126 patients suffering unstable angina pectoris to receive treatment in our hospital from Feb. 2013 to Jul. 2015 were selected and randomly divided into an observation group（esmolol ＋ diltiazem; n=63）and a control group（diltiazem; n=63）. The curative effects and the situations of angina pectoris before and after the treatment between the two groups were compared and the related factors influencing the prognosis were analyzed. Results The total effective rate in the observation group was 91.91%, and that in the control group was 73.02%, with a statistically significant difference（P 〈0.05）. Before the treatment, the frequency and duration of angina pectoris, plasma viscosity and fibrinogen levels between the two groups had no significant difference（P〈 0.05）; after the treatment, the above indicators in the two groups significantly decreased, and the changes in the observation group were larger（P〈 0.05）. Multivariate logistic regression analysis showed that Braunwald classification, frequency and duration of angina pectoris, CK-MB and c Tn I were independent influencing factors for prognosis of unstable angina pectoris（P〈 0.05）. Conclusion Esmolol combined with diltiazem in the treatment of unstable angina pectoris has significant curative effects and can effectively alleviate the clinical symptoms; Braunwald classification, frequency and duration of angina pectoris, CK-MB and c Tn I are independent influencing factors for prognosis of unstable angina pectoris.

关 键 词：艾司洛尔 地尔硫卓 心绞痛 疗效 影响因素 

分 类 号：R541.4[医药卫生—心血管疾病]