Src家族蛋白酪氨酸激酶(SFKs)对血管内皮细胞通透性的调节作用  

The role of Src family protein tyrosine kinases in regulating permeability of vascular endothelial cell

作　　者：王平忠[1] 王晓艳[1] 姜泓[1] 杜虹[1] 申焕君[1] 李璟[1] 

机构地区：[1]第四军医大学唐都医院传染科,陕西西安710038

出　　处：《转化医学电子杂志》2017年第1期7-10,共4页E-Journal of Translational Medicine

基　　金：国家自然科学基金(81373118)

摘　　要：血管内皮细胞是机体重要的屏障和半透膜.溶质渗出主要经细胞旁途径和穿细胞途径,分别与细胞屏障结构受损和质膜小凹(caveolae)或囊泡的形成与分离有关.Src家族蛋白酪氨酸激酶(SFKs)可使一些屏障结构蛋白(如VE-cadherin、连环蛋白、踝蛋白、纽蛋白)和质膜小凹形成与分离相关的蛋白(如小凹蛋白-1、发动蛋白-2)磷酸化,破坏屏障结构和增加质膜小凹的形成与分离.因此,SFKs对血管内皮细胞通透性具有重要的调节作用.本文就SFKs如何调节血管内皮细胞通透性做一详细介绍.Vascular endothelial cells form a semi-permeable barrier between blood and tissue. The paracellular pathway and the transcellular pathway are main channels of solutes leakage.They are associated with disorganization of cellular barrier and formation and fission of caveolae or vesicles,respectively. Src family protein tyrosine kinases（ SFKs） induce the phosphorylation of many important proteins in barrier（ VE-cadherin,catenin,talin,vinculin） and caveolae structure（ caveolin-1,dynamin-2）,leading to damage of cellular barrier and increase of caveolae formation and fission. Therefore,SFKs plays an importmant role in regulating permeability of vascular endothelial cell. In this study,we make a detailed introduction that how SFKs regulates the permeability of vascular endothelial cell.

关 键 词：Src家族蛋白酪氨酸激酶 内皮细胞通透性 细胞连接 磷酸化 

分 类 号：Q28[生物学—细胞生物学]