他莫昔芬治疗Ⅲ型前列腺炎疗效观察  

Therapeutical effect of tamoxifen on type Ⅲ prostatitis

作　　者：张新明[1] 何海填[1] 郭德迎 叶宗岳[1] 

机构地区：[1]深圳市蛇口人民医院泌尿外科,广东深圳518067

出　　处：《现代临床医学》2017年第1期54-56,共3页Journal of Modern Clinical Medicine

基　　金：广东省医学科学技术研究基金项目(编号B2015138)

摘　　要：目的:观察他莫昔芬治疗Ⅲ型前列腺炎的临床疗效并探讨其作用机理。方法:将80例患者分为Ⅲ型前列腺炎合并特发少精症组28例和特发少精症组52例,均采用他莫昔芬治疗,疗程均为12周。比较2组治疗前后的前列腺常规、慢性前列腺炎症状指数(NIH-CPSI)、精浆中细胞因子的表达、勃起功能国际问卷(IIEF-5)评分。结果:(1)治疗后,Ⅲ型前列腺炎组NIH-CPSI评分显著降低(P<0.05),IIEF-5评分显著升高(P<0.05);(2)Ⅲ型前列腺炎组WBC、TNF-α、IL-8、IL-10的水平显著降低(P<0.05);(3)2组的NIH-CPSI评分与WBC、TNF-α、IL-8、IL-10水平呈正相关,而IIEF-5评分与WBC、TNF-α、IL-8、IL-10水平呈负相关。结论:Ⅲ型前列腺炎合并特发少精症组患者通过他莫昔芬治疗,能使NIHCPSI评分显著降低和IIEF-5评分显著提高,且减少前列腺液中炎症因子的表达。Objective： To observe the therapeutical effect of tamoxifen on type Ⅲ prostatitis, and to of action. Methods： 80 patients were randomly divided into the two groups： type Ⅲ prostatitis with idiopathic oligospermia group （abbreviated as type Ⅲ prostatitis group, 28 cases） and idiopathic oligospermia group （52 cases）. Both groups were given tamoxifen for 12- week courses of treatment 12 weeks later, prostatic routine test, scores of National InstiProstatitis Symptom Index （ NIH-CPSI）, the expression of cytokines in seminal plasma, and International Index of ErectileFunction-5 （IIEF-5） were compared between the two groups. R esults： （ 1 ） The NIH-CPSI score of type Ⅲ prostatitis group significantly decreased （ P 〈 0. 05 ） while the IIEF-5 score significantly increased after treatment （P 〈 0. 05 ）. （ 2 ） Type ＇ prostatitis group indicated significantly lower levels of WBC, TNF-α, IL-8 and IL-10（ P 〈 0. 05 ）. （ 3 ）positive correlation with the levels of WBC, TNF-α, IL-8 and IL-10 while the IIEF-5 score was in the two groups. Conclusion： The treatment of type ＇ prostatitis with idiopathic oligospermia with tamoxifen can significantly reduce the NIH-CPSI score and increase nEF-5 score, and reduce the expression of inflammatory fe to rs in the prostatic fluid.

关 键 词：他莫昔芬 Ⅲ型前列腺炎 特发少精症 机理 

分 类 号：R697.33[医药卫生—泌尿科学]