PPAR-γ对糖尿病视网膜病变的潜在治疗作用  

Recent progress in investigation of potential therapeutic action of PPAR-γ in the diabetic retinopathy

作　　者：蒋玲[1] 

机构地区：[1]彭州市人民医院眼科,四川611930

出　　处：《国际眼科纵览》2016年第6期391-394,共4页International Review of Ophthalmology

摘　　要：糖尿病视网膜病变（diabeticretinopathy，DR）是致盲的重要原因，炎症反应在其发病过程中发挥着重要作用。过氧化物酶体增生物激活受体-γ（peroxisomeproliferator—activatedreceptor-γ，PPAR-γ）不仅具有增加胰岛素敏感性的作用，还可以抑制炎症和细胞增殖等，因而激活PPAR—γ可能对DR发挥一定的治疗作用。本文就PPAR-γ的生物学功能、PPAR-γ在DR中的作用机制及对DR的可能治疗作用做一综述。Diabetic retinopathy is an important cause of blindness. Inflammatory processes have an important role in the diabetic retinopathy. Peroxisome proliferator-activated receptor-γ（PPAR-γ） not only increases insulin sensitivity, but also inhibits inflammatory processes and cell proliferation. Therefore, acti- vation of PPAR-γ may be effective for treating diabetic retinopathy. Those functions of PPAR-y and ideas for medicine therapeutic to diabetic retinopathy are summarized in this review.

关 键 词：糖尿病视网膜病变 过氧化物酶体增生物激活受体-Γ 糖尿病 

分 类 号：R587.2[医药卫生—内分泌]