哈萨克族妇女妊娠期缺铁性贫血对新生儿血清铁水平的影响  

Influence of iron deficiency anemia during pregnancy in Kazakh nationality women on neonatal serum iron level

作　　者：王晓燕[1] 张小荣[1] 买里古尼.米来 鲁春雁[1] 贾长茹[2] 

机构地区：[1]阿勒泰地区人民医院产科,新疆阿勒泰836500 [2]哈尔滨医科大学第四附属医院产科,黑龙江哈尔滨150001

出　　处：《中国妇幼健康研究》2016年第12期1453-1456,共4页Chinese Journal of Woman and Child Health Research

基　　金：新疆维吾尔自治区卫生厅青年科技基金(项目编号:2013Y06)

摘　　要：目的探讨哈萨克族妇女妊娠期缺铁性贫血对新生儿血清铁水平的影响及干预措施分析。方法选取2014年5月至2015年12月阿勒泰地区人民医院产科的196例哈萨克族妊娠期缺铁性贫血患者为研究对象,分别在孕早中晚期测定相关指标,全程测定研究对象怀孕期间的血红蛋白（Hb）、网织红细胞（Ret）、网织红细胞成熟指数（RMI）、血清铁（SI）、血清铁蛋白（SF）和血清转铁蛋白受体（s TfR）。分析三组患者孕早中晚期不同时间段缺铁性贫血与新生儿血清铁水平,并研究分析相关干预措施。结果缺铁性贫血（IDA）、隐性铁缺乏症（LID）和正常组的患病率在不同孕周组有显著性差异（χ2值分别为8.82、8.18、36.58,均P〈0.05）,其患病率随着孕周的增加而增加。SI与SF随着孕周的增加指数逐渐降低,s TfR,Ret及RM I随着孕周的增加逐渐上升,Hb、SI、SF、s TfR、Ret和RMI在不同孕周中有显著性差异（F值分别为5.17、9.49、7.49、4.81、5.19、6.28,均P〈0.05）,SI、SF在不同孕周中有显著性差异（F值分别为7.16、3.48,均P〈0.05）,进一步两两比较显示,LDA组、LID组与正常组SI和SF相比有显著性差异（t值3.48～7.16,均P〈0.05）,其余指标无显著性差异（P〉0.05）。Hb在孕中期达到最低（112.49±2.95g/L）,孕晚期有所回升（115.72±0.09g/L）,而SI与SF随着孕周的增加逐渐降低,孕晚期分别为（75.82±0.85g/L和15.45±0.08g/L）,各孕期相比较,F值分别为9.49和7.49。结论妊娠期妇女随着孕期的不断增加,缺铁现象不断加重,但是孕早期的缺铁现象对新生儿血清铁的影响最大,应该受到极大重视。妇女在备孕或妊娠期应遵医嘱,按时产检,并进行血清铁化验,医生要对早中晚期孕妇采取合理的治疗措施。Objective To explore the influence of iron deficiency anemia during pregnancy in Kazakh nationality women on neonatal serum iron level and the intervention measures. Methods Totally 196 cases of Kazakh nationality patients with iron deficiency anemia during pregnancy in the obstetrics department of Altay Region People＇s Hospital from May 2014 to December 2015 were selected as research objects,and relevant indicators were measured in different pregnancy period. Hemoglobin（ Hb）,reticulocyte（ Ret） and reticulocyte maturity index（ RMI）,serum iron（ SI）,serum ferritin（ SF） and serum transferrin receptor（ s TfR） were determined in the whole gestation. Correlation between iron deficiency anemia in different pregnancy period and neonatal serum iron level in three groups was analyzed to explore intervention measures. Results Iron deficiency anemia（ IDA）,latent iron deficiency（ LID） and the prevalence of iron deficiency in different gestational age groups had significant difference（ χ2value was 8. 82,8. 18 and 36. 58,respectively,all P〈 0. 05）,and its prevalence increased with the increase of gestational age. SI and SF gradually reduced with the increase of gestational age,while s TfR,Ret and RMI gradually rose with the increase of gestational age. Hb,SI,SF,and s TfR,Ret and RMI had significant differences in different gestational age（ F value was 5. 17,9. 49,7. 49,4. 81,5. 19 and 6. 28,respectively,all P 〈0. 05）. Further group comparison showed that differences in Hb between the first and second trimester,SF between the second,third trimester and first trimester,Ret and RMI between the first,second trimester and third trimester were statistically significant（ t value ranged 4. 81 to 9. 49,all P 〈0. 05）. SI and SF were significantly different among patients in different gestational age（ F value was 7. 16 and 3. 48,respectively,both P〈 0. 05）.Further group comparison revealed that SI and SF among IDA group,LID group and normal group were remarkably different（ t val

关 键 词：哈萨克族 妊娠期缺铁性贫血 胎儿 血清铁水平 影响 

分 类 号：R714.2[医药卫生—妇产科学]