呼吸机相关性肺损伤与炎症反应  

Ventilator-associated lung injury and inflammatory reaction

作　　者：孙慧男[1] 陈旭昕[2] 韩志海[1] Sun Huinan Chen Xuxin Han Zhihai(Department of Respiratory Medicine, Navy Clinical Medicine College of The Second Military Medical University, Beijing 100048, China)

机构地区：[1]第二军医大学海军临床医学院呼吸科,北京100048 [2]海军总医院呼吸科,北京100048

出　　处：《国际呼吸杂志》2016年第24期1890-1893,共4页International Journal of Respiration

基　　金：军队后勤科研计划重点项目（BHJ16J011）;海军总医院归国人员创新技术项目启动基金（GGCX201208）

摘　　要：呼吸机相关性肺损伤是由于机械牵张和高浓度氧吸入等因素触发多种肺组织细胞的感受器，激活阳离子通道、模式识别受体、丝裂原活化蛋白激酶等多种信号传导通路，引起细胞因子、趋化因子和黏附分子的合成与释放，诱发过度炎症反应，造成肺组织损伤。因此，对呼吸机相关性肺损伤中炎症反应的触发机制、作用通路及炎症因子做深入研究，可以为呼吸机相关性肺损伤的防治工作提供借鉴。Ventilator-associated lung injury is due to mechanical stretch and high concentration oxygen inhalation and other factors that trigger a variety of lung tissue cell receptors,activated cation channel,pattern recognition receptors and mitogen activated protein kinase and other signaling pathways, causing cell factor,trend of the synthesis and release of cytokines and adhesion molecules and induce excessive inflammatory reaction,resulting in pulmonary tissue damage.Therefore,the study of the trigger mechanism,action pathway and inflammatory factors of the inflammatory response in ventilator induced lung injury can provide a reference for the prevention and treatment of ventilator-associated lung injury.

关 键 词：机械通气 肺损伤 呼吸机相关性 炎症反应 信号传导通路 炎症因子 

分 类 号：R563[医药卫生—呼吸系统]