用药动作线索诱发海洛因戒断者的镜像神经活动:一项fMRI研究  

Observation drug using action elicited mirror neuron reactivity in the abstinent heroin users: An fMRI study

作　　者：苏得权[1,2] 曾红[1,2] 陈骐[3] 叶浩生[1,2] 

机构地区：[1]广州大学心理系 [2]广州大学心理与脑科学研究中心,广州510003 [3]华南师范大学心理学院,广州510631

出　　处：《心理学报》2016年第12期1499-1506,共8页Acta Psychologica Sinica

基　　金：国家自然科学基金(31271113)资助

摘　　要：相关线索能够诱发药物依赖者的心理渴求,而健康人不会对相关线索产生心理渴求。15名海洛因成瘾者和12名没有任何物质滥用的健康被试参与实验,收集了他们在观看相关线索与对照线索时的脑神经活动。结果发现,药物线索能够诱发戒断者更多脑区的活动,包括扣带回和楔前叶。两组被试在对照动作线索刺激诱发作用下,其颞叶、顶叶均出现了较为一致的活动。在用药动作线索诱发作用下,戒断组双侧颞中回、双侧顶下小叶、左侧顶上小叶和右侧额下回显示出显著活动,并且与对照动作线索激活脑区一致;健康组被试除枕叶-颞叶联合区外,没有出现显著的脑区活动。以上结果表明,用药动作线索诱发了海洛因戒断者颞中回、顶下小叶、额下回等镜像神经系统的活动,这些脑区对不同类型的相关线索十分敏感,它们可能通过对用药动作的心理模拟,参与了用药动作线索的快速自动化加工。The cue-provoked craving is one of the main reasons for psychological dependence. The current study applied cue reactivity paradigm to find out the activation of whole brain in the drug dependent individual＇s brain when they exposed in the related cues. 15 abstinent heroin dependent individuals （AHD） and 12 no-drug use health participants （NDP） involved in the experiment. We conducted 2 （groups： abstinent drug dependent group, no-drug use group）×2 （related condition： related cue, unrelated cue）×2 （cue types： static object, action） experiment design. They observed the cue-related stimuli and the counterpart cue stimuli while lying in a 3.0T Siemens MRI scanner. Images for heroin-related stimuli contained heroin injection, preparation, and paraphernalia. Neutral images （control） were composed of daily life objects and behavior. We explored and analysis the neuron activation of cue-induced reactivity between the two groups. Conjunction analysis of action related cue and unrelated cue, to explore the difference activity of mirror neuron system within the two conditions and between AHD and NDP. Multiple t-contrasts between related-cues and unrelated-cues were conducted to find out the cue neuronal reactivity which was accompanied with craving. The result showed that drug-related cues activated more brain regions than the corresponding cues which include the occipital-temporal cortex, superior parietal lobule and inferior parietal lobule, orbit-frontal cortex, anterior cingulate cortex and posterior cingulate, hippocampus, thalamus and midbrain for the AHDs. The comparison between activated brain area under drug and ＂C-drug＂ cues showed more activation in right hippocampus, precuneus and the posterior cingulate activation for abstinent group. The hemodynamic response in temporal and parietal lobe correlated was consistent when we performed t-contrasts between ＂C-action＂ and ＂C-drug＂ condition for both of the two group subjects. Abstinent subjects evoked the bilateral midd

关 键 词：心理渴求 镜像神经 具身认知 

分 类 号：B845[哲学宗教—心理学]