丙酮酸钠鼻喷剂治疗变应性鼻炎的效果分析  

Treatment effect of sodium pyruvate nasal spray on allergic rhinitis

作　　者：李丽莎[1] 王瑞琦[1] 关凯[1] 

机构地区：[1]中国医学科学院北京协和医院变态反应科,北京100730

出　　处：《临床耳鼻咽喉头颈外科杂志》2017年第2期103-106,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:评价丙酮酸钠鼻喷剂对变应性鼻炎患者的治疗作用。方法:采用单中心、随机、平行对照研究方法,共招募53例对蒿属花粉过敏的变应性鼻炎成年患者。在蒿属花粉季进行试验,前2周统一使用鼻用糖皮质激素标准剂量进行治疗,其后患者随机分为2组,实验组(n=23)使用丙酮酸钠鼻喷剂,对照组(n=30)不使用,持续观察2周,比较2组患者的日症状评分和其他抗炎药物评分,以及鼻腔呼出气一氧化氮(nNO)的水平。结果:在2组患者基线人口学特征和过敏症状严重程度一致的前提下,实验组的日症状评分为1.4±0.6,显著低于对照组(1.7±0.4),差异有统计学意义(P=0.006);实验组的其他抗炎药物评分为(4.8±1.2),也显著低于对照组(5.8±1.2),差异有统计学意义(P=0.000)。实验组nNO结果为(596.3±134.6)ppb,低于对照组(709.6±311.3)ppb,但差异无统计学意义(P=0.408)。结论:使用丙酮酸钠鼻喷剂可能会减轻变应性鼻炎患者的症状,减少其他抗炎药物的使用量,其应用价值和作用机制值得进一步研究。Objective：Pyruvate is a key intermediate in several metabolic pathways of human body Sodium pyruvate possesses anti-oxidation and anti-inflammatory effects,which make it a possible novel therapy for allergic rhinitis.However,the relevant clinical research is rare.The aim of the present study is to evaluate the treatment effect of sodium pyruvate nasal spray on allergic rhinitis.Method：This was a randomized,parallel-group,singlecenter study,and 53 adult patients with seasonal allergic rhinitis caused by Artemisia pollen were recruited.In the pollen season,all the participants were given corticosteroid nasal spray of standard dose for two weeks,and during the next two weeks they were randomized to treatment group（n=23）taking nasal sodium pyruvate,and control group（n=30）without sodium pyruvate.Daily rhinoconjunctivitis symptom score and daily rescue medication score were analyzed.Also the fraction of exhaled nitric oxide of the upper airway was measured before and after the treatment of sodium pyruvate.Result：The demographic characteristics and baseline disease severity were not significantly different between the treatment group and control group.Both the daily symptom score（1.4±0.6vs 1.7±0.4,P=0.006）and rescue medication score（4.8±1.2vs 5.8±1.2,P=0.000）of the treatment group was significantly lower than the scores of control group.In addition,nasal fraction of exhaled nitric oxide of the treatment group（596.3±134.6）ppb tended to be lower than control group（709.6±311.3）ppb,although the difference was not significant,P=0.408.Conclusion：Sodium pyruvate nasal spray was effective in attenuating the rhinoconjunctivitis symptoms and reducing the rescue medication use of allergic rhinitis patients.The application value and mechanism of action of sodium pyruvate are worth further studying.

关 键 词：丙酮酸钠 鼻炎 变应性 蒿属花粉 治疗效果 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]