用2种不同温度生理盐水行鼻腔冲洗对变应性鼻炎患者临床症状及炎性因子水平的影响  

Effect of saline nasal irrigation with different temperature on the clinical symptoms and the level of inflammatory factors in patients with allergic rhinitis

作　　者：高中[1] 张宇[1] 周波[1] 

机构地区：[1]湖北医药学院附属东风医院耳鼻咽喉头颈外科,湖北十堰442008

出　　处：《临床耳鼻咽喉头颈外科杂志》2017年第2期135-137,141,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:研究用2种不同温度生理盐水行鼻腔冲洗对变应性鼻炎患者临床症状及炎性因子水平的影响。方法:将120例变应性鼻炎患者随机分为对照组(n=60)和实验组(n=60),2组患者均行特异性免疫治疗,对照组采用25℃生理盐水进行鼻腔冲洗,实验组采用40℃生理盐水进行鼻腔冲洗。比较2组患者的疗效、临床症状和炎性因子水平。结果:实验组显效率为63.33%,有效率为31.67%,无效率为5.00%,总有效率为95.00%;对照组总有效率仅为76.67%,差异有统计学意义(P<0.05)。治疗前实验组和对照组的鼻塞、流涕、鼻痒、喷嚏等症状评分相近(P>0.05),治疗后实验组鼻塞和喷嚏评分低于对照组(P<0.05),2组患者的流涕和鼻痒评分相近(P>0.05)。治疗前实验组和对照组组胺、嗜酸粒细胞阳离子蛋白、白三烯C4和特异性IgE等炎性因子水平相近(P>0.05),治疗后实验组组胺和白三烯C4水平低于对照组(P<0.05),2组患者的嗜酸粒细胞阳离子蛋白水平和特异性IgE水平相近(P>0.05)。结论:变应性鼻炎患者在特异性免疫治疗基础上用40℃生理盐水鼻腔冲洗可以降低组胺和白三烯C4水平,改善鼻塞和喷嚏症状,临床疗效较好。Objective：To study the effect of nasal spray on the clinical symptoms and the level of inflammatory factors in patients with allergic rhinitis by salines with different temperature normal salines.Method：One hundred and twenty patients were divided into control group（n=60）and experimental group（n=60）randomly and all the patients were given specific immunotherapy.The patients in control group were treated with saline in 25 degrees for nasal douche,while the patients in the experimental group were treated with saline in 40 degrees.Clinical symptoms and inflammatory factors were compared between two groups.Result：In the experimental group,,the total effective rate was 95.00%,while the control group was only 76.67%.The difference was statistically significant（P〈0.05）.Before treatment,the symptoms scores of nasal congestion,runny nose,nasal itching,sneezing and other symptoms were similar in two groups（P〉0.05）.After treatment,nasal congestion and sneezing score in experimental group was lower than that in the control group（P〈0.05）.The scores of runny nose and nasal itching score is similar in two groups（P〉0.05）.Before treatment,the histamine and eosinophil cationic protein（ECP）,leukotriene C4 and specific IgE inflammatory factor level were similar in two groups（P〉0.05）.After treatment,histamine and leukotriene C4 levels in experimental group is lower than that in the control group（P〈0.05）.Conclusion：Forty degrees saline nasal irrigation can reduce histamine and leukotriene C4 level in patient with allergic rhinitis,improving the symptoms of nasal congestion and sneezing.

关 键 词：温度 生理盐水 鼻腔冲洗 鼻炎 变应性 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]