黄葵胶囊对糖尿病肾病血液透析患者微炎症和氧化应激状态的影响  

Effects of Huangkui Capsules on Oxidative Stress and Micro-inflammation State in Diabetic Nephropathy Patients with Maintenance Hemodialysis

作　　者：赵金香 李耀华[2] 谢萍[3] 

机构地区：[1]甘肃医学院,甘肃平凉744000 [2]甘肃中医药大学,甘肃兰州730000 [3]甘肃省人民医院,甘肃兰州730000

出　　处：《中国中医药信息杂志》2017年第2期21-24,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：甘肃省卫生行业科研计划项目(GSWSKY-2015-04)

摘　　要：目的观察黄葵胶囊对糖尿病肾病维持性血液透析患者微炎症和氧化应激状态的治疗作用。方法选择2014年甘肃省人民医院透析时间>6个月的糖尿病肾病患者46例,随机分为观察组和治疗组各23例,同时选取20名健康体检者作为对照组。观察组给予常规枸橼酸碳酸氢盐血液透析治疗,每次4 h,每周3次;治疗组在此基础上加用黄葵胶囊,每次2.5 g,每日3次,口服。观察组和治疗组均治疗8周,检测治疗前后血浆中炎症指标高敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、白细胞(WBC)及氧化应激指标丙二醛(MDA)、循环晚期氧化蛋白产物(AOPP)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)变化。结果与对照组比较,观察组和治疗组治疗前hs-CRP、IL-6、TNF-α、WBC、MDA和AOPP水平明显升高(P<0.01),SOD和GSH-Px水平明显降低(P<0.01);观察组和治疗组比较差异无统计学意义(P>0.05)。治疗后,观察组IL-6、hs-CRP、MDA和AOPP水平明显升高(P<0.05),GSH-Px和SOD水平明显降低(P<0.05),TNF-α和WBC无显著变化(P>0.05);治疗组IL-6、TNF-α、hs-CRP、WBC、MDA和AOPP水平明显降低(P<0.01),SOD和GSH-Px水平均明显升高(P<0.01);治疗后观察组与治疗组上述各指标比较,差异均有统计学意义(P<0.01)。结论糖尿病肾病维持性血液透析患者体内普遍存在微炎症和氧化应激状态,黄葵胶囊可改善患者微炎症和氧化应激状态。Objective To investigate the effects of Huangkui Capsules on oxidative stress and micro-inflammation state in diabetic nephropathy patients with maintenance hemodialysis. Methods Forty-six patients with diabetic nephropathy who had received maintenance hemodialysis for over six month in Gansu Provincial People＇s Hospital were randomly divided into observation group（23 cases） and treatment group（23 cases） from January to December in 2014. Twenty healthy subjects who had physical examinations were selected as the control group at the same time. Observation group were given conventional hemodialysis for 4 hours, 3 times a week; treatment group were given conventional hemodialysis combined with Huangkui Capsules, orally, 2.5 g each time, 3 times a day. Both groups were treated for 8 weeks. Blood was collected before and after treatment for detection of hypersensitive C-reactive protein（hs-CRP）, interleukin-6（IL-6）, tumor necrosis factor alpha（TNF-α）, white blood cell（WBC）, malondialdehyde（MDA）, cycle of advanced oxidation protein products（AOPP）, superoxide dismutase（SOD） and glutathione peroxidase（GSH-Px） levels. Results The levels of IL-6, TNF-α, AOPP, WBC, MDA and hs-CRP were significantly higher in the observation group and the treatment group compared with the control group before treatment（P〈0.01）, SOD and GSH-Px levels decreased（P〈0.01）; there was no statistical significance between the observation group and the treatment group（P〈0.05）. After treatment, the levels of IL-6, hs-CRP, MDA and AOPP increased in the observation group（P〈0.05）, GSH-Px and SOD decreased（P〈0.05）, there were no statistical significance in TNF-α and WBC（P〈0.05）; The levels of AOPP, TNF-α, hs-CRP, WBC, MDA and IL-6 in treatment group significantly decreased（P〈0.01）, GSH-Px and SOD significantly increased（P〈0.01）; there was statistical significance between the observation group and the treatment group（P〈0.01）. Conclusion Micro-inflammation sta

关 键 词：黄葵胶囊 糖尿病肾病 维持性血液透析 微炎症 氧化应激 

分 类 号：R259.872[医药卫生—中西医结合]