自拟消痞方治疗糖尿病胃轻瘫临床研究  

Clinical Study on Treatment of Diabetic Gastroparesis on Self-designed Xiaopi Formula

作　　者：张月[1] 董艳[1] 王倩[1] 周静[1] 杨玉青[1] 张媛媛[1] 晏丽丽[1] 张英来[1] 柳治 

机构地区：[1]唐山市中医医院,河北唐山063000 [2]华北理工大学附属医院,河北唐山063000

出　　处：《中国中医药信息杂志》2017年第2期25-28,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(2013256)

摘　　要：目的观察自拟消痞方治疗糖尿病胃轻瘫(DGP)的临床疗效。方法采用随机数字表法将200例DGP患者分为观察组和对照组各100例,2组均予胰岛素皮下注射或口服降糖药等常规降糖方案。对照组予多潘立酮片,每次1片,每日3次,口服;观察组予自拟消痞方加减,每日1剂,早晚分服。2组均以1个月为1个疗程,观察3个疗程。观察2组临床疗效及治疗前后胃排空率、糖化血红蛋白(Hb A1c)、血液流变学指标。结果观察组总有效率(94.0%)高于对照组(82.0%),差异有统计学意义(P<0.05)。2组血糖水平均降低,胃排空率提高,观察组明显优于对照组(P<0.05);对照组治疗后血液流变学指标无明显改善(P>0.05),观察组改善显著(P<0.05),与对照组比较差异有统计学意义(P<0.05)。结论自拟消痞方治疗DGP疗效显著,可提高患者胃排空率及降低Hb A1c水平,改善血液流变学指标。Objective To observe the clinical efficacy on the treatment of diabetic gastroparesis of self-designed Xiaopi Formula. Methods Totally 200 cases of DGP were divided into the observation group and the control group with random number table, with 100 cases in each group. Two groups were given the general treatment scheme, such as the subcutaneous injections of insulin or oral hypoglycemic medicine. The patients in the control group were treated with Domperidone orally, one tablet each time, 3 times a day; while the patients in the observation group were treated with self-designed Xiaopi Formula, twice a day, one time for morning and one time for evening. One course lasted for one month, 3 courses in total. Clinical efficacy and the change of gastric emptying rate, glycosylated hemoglobin and hemorrheology in the two groups were observed. Results Total effective rate of observation group（94.0%） was higher than that of the control group（82.0%）, with statistical significance（P〈0.05）. After treatment, blood sugar decreased and gastric emptying rate improved in both groups（P〈0.05）, and observation group was superior to control group（P〈0.05）; The control group in terms of improving hemorrheology had no obvious significance（P〉0.05）; Observation group can obviously improve the indexes of blood rheology, with statistical significance with control group（P〈0.05）. Conclusion The clinical efficacy of self-designed Xiaopi Formula for the treatment of diabetic gastroparesis is obvious, which can promote gastric emptying rate and decrease Hb A1 c level, and improve blood rheology.

关 键 词：糖尿病 胃轻瘫 自拟消痞方 疗效评价 

分 类 号：R259.872[医药卫生—中西医结合]