云南省一类疟区间日疟原虫IgG抗体血清流行病学调查  

Investigation of serum immunoglobulin G of Plasmodium vivax of residents living in class Ⅰ regions of malaria epidemic in Yunnan Province

作　　者：王剑[1] 林祖锐[1] 吕全[1] 李建雄[1] 赵晓涛[1] 许时燕[1] 徐艳春[1] 孙晓东[1] WANG Jian LIN Zurui LV Quan LI Jianxiong ZHAO Xiaotao XU Shiyan XU Yanchun SUN Xiaodong(Yunnan Institute of Parasitic Disease, Yunnan Center for Malaria Research, Yunnan Provincial Key Laboratory of Vector- borne Diseases Control and Research, Yunnan Provincial Center of Arborvirus Research, Yunnan Provincial Collaborative Innovation Center for Public Health and Disease Prevention and Control, Pu＇ er, Yunnan 665000, Chin)

机构地区：[1]云南省寄生虫病防治所,云南省疟疾研究中心,云南省虫媒传染病防控研究重点实验室,云南省虫媒病毒研究中心,云南公共卫生与疾病防控协同创新中心,云南普洱665000

出　　处：《中国热带医学》2016年第12期1174-1177,共4页China Tropical Medicine

基　　金：云南省中青年学术技术带头人后备人才项目(No.2015HB075)

摘　　要：目的监测云南省一类疟区人群的间日疟原虫抗体(Ig G)水平,为云南省消除疟疾行动的流行预测和防控效果评价提供科学依据。方法 2013—2014年在云南6个一类疟区县(市)采用分层随机抽样采集居民滤纸血膜,采用ELISA试剂盒检测间日疟原虫特异性抗体,采用SPSS 20.0统计软件进行抗体阳性率及抗体滴度检验,变量间相关性进行Pearson分析。结果共检测腾冲、盈江、耿马、瑞丽、孟连、盐津6县(市)的7 050份血样,间日疟原虫抗体(Ig G)阳性率为9.05%,各县间抗体阳性率差异有统计学意义(P<0.05),且5个边境县的平均抗体阳性率显著高于内地县盐津的阳性率,差异有统计学意义(P<0.05);女性的阳性率9.98%显著高于男性7.95%,差异有统计学意义(P<0.05);学生的阳性率10.79%显著高于居民7.74%,差异有统计学意义(P<0.05);少年儿童、青壮年和中老年组的阳性率分别为9.52%、7.59%和9.40%,各组间差异无统计学意义(P>0.05);全省合计及6个县(市)2013年和2014年的抗体阳性率差异均无统计学意义(P>0.05)。结论云南省一类疟区的人群间日疟原虫抗体(lg G)水平能反映前期的疟疾流行强度,女性、学生人群间日疟原虫抗体水平高的现象值得重视。Objective To investigate the level of serum immunoglobulin G（Ig G） of Plasmodium vivax（Pv.）of residents living in class Ⅰ regions of malaria epidemic in Yunnan Province, so as to provide the evidence for malaria epidemic prediction and adjustment of prevention and control measures during the period of project of malaria elimination. Methods The blood samples of people living in six class Ⅰ regions of malaria epidemic from 2013 to 2014 were collected in filter paper and the titer of specific Ig G of Pv. in sera were determined by ELISA kit. The data were analyzed by SPSS 20.0, and the Pearson correlation analysis was used in variables. Results A total of 7 050 blood samples from Tengchong County,Yingjiang County, Gengma County, Ruili City, Menglian County and Yanjing County were collected. The positive rate of serum specific Ig G of Pv. was 9.05%. The positive rates of the five counties located in the border area were higher than that of Yanjing County being far away from the border（P〈0.05）. The positive rate of serum specific Ig G of Pv. of the females was9.98%, which was higher than that of the males（7.95%）（P〈0.05）. The positive rate of serum specific Ig G of Pv. of the students was 10.79%, which was higher than that of the residents（7.74%）（P〈0.05）. The positive rates of serum Ig G of Pv. in children and youth, young adults and older adults were 9.52%, 7.59% and 9.40%.respectively and no significant differences were observed（P〉0.05）. The positive rates of serum Ig G of Pv. had no significant difference between the investigated six counties and the whole Yunnan Province（P〉0.05）. Conclusion The level of the titer of serum Ig G of Pv. of class Ⅰ regions of malaria epidemic can reflect the early epidemic condition of Yunnan Province. The higher level of the titer of serum Ig G of Pv. in the females and students should be paid attention to.

关 键 词：间日疟原虫 IGG抗体 血清学 

分 类 号：R531.3[医药卫生—内科学]