低分子肝素联合华法林及丹参多酚酸盐治疗中、低危急性肺栓塞患者的疗效  

Efficacy of Low Molecular Weight Heparin,Warfarin and Salvia Miltiorrhiza Polyphenols Treating Patients with Low or Intermediate Risk Acute Pulmonary Embolism

作　　者：罗培[1] 刘冬梅[1] 房建斌 顾小卫[1] 吴明明[1] 张巍[1] 曲晨[2] 

机构地区：[1]如东县人民医院心血管内科,江苏南通226400 [2]南京医科大学第二附属医院老年科,江苏南京210000

出　　处：《贵州医科大学学报》2017年第1期97-100,104,共5页Journal of Guizhou Medical University

基　　金：国家自然科学基金青年项目(81501202)

摘　　要：目的:探讨低分子肝素联合华法林及丹参多酚酸盐治疗中、低危急性肺栓塞患者的临床疗效及安全性。方法:80例中、低危急性肺栓塞患者随机分为研究组和对照组,对照组给予低分子肝素加华法林进行治疗,研究组在对照组基础上给予丹参多酚酸盐进行治疗,比较两组患者治疗的总有效率、呼吸频率、心率、血气分析指标、血凝指标、住院时间、住院费用以及不良反应发生率。结果:研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗后,研究组呼吸频率、心率低于对照组(P<0.05),PaO_2、PaCO_2值明显高于对照组(P<0.05),PT、APTT长于对照组(P<0.05);研究组住院时间及住院费用与对照组相比均明显减少(P<0.05),研究组不良反应发生率与对照组相比差异不具有统计学意义(P>0.05)。结论:采用低分子肝素联合华法林及丹参多酚酸盐对中、低危急性肺栓塞临床疗效较好,可有效改善呼吸循环功能。Objective： To investigate the safety and acute pulmonary embolism treated with low molecular efficacy of patients with low or intermediate risk weight heparin, warfarin and Salvia miltiorrhiza polyphenols. Methods： 80 cases of patients with low or intermediate risk acute pulmonary embolism were divided into research group and control group; the control group was treated with low molecular weight heparin combined with warfarin, and the research group were treated with Salvia miltiorrhiza polyphenols on the basis of the control group treatment. Total effective rate, respiratory rate, heart rate, blood gas index, blood coagulation index, length of stay, cost of hospitalization, and incidence of adverse reactions of the two groups were compared. Results： The total effective rate of the study group was significantly higher than that of the control group, difference was statistically significant （P 〈 0. 05）. The length of stay and cost of hospitalization of the study group were significantly lower than that of the control group （ P 〈 0.05 ）. The incidence rate of adverse reactions in study group compared with the control group was not significant （ P 〉 0.05 ）. Conclusion： The use of low molecular weight heparin, warfarin and Salvia miltiorrhiza polyphenols on low or intermediate risk acute pulmonary embolism treatment clinical curative effect is good. It can effectively improve the respiratory function.

关 键 词：肺栓塞 肝素 低分子量 华法林 丹参多酚酸盐 血气分析 

分 类 号：R563.5[医药卫生—呼吸系统]