蛇床子素对肾脏缺血-再灌注损伤的作用研究  

Effect of osthole on renal ischemia reperfusion injury

作　　者：赵佰桥[1] 刘剑华[1] 

机构地区：[1]连云港市第一人民医院肾内科,江苏连云港222002

出　　处：《实用药物与临床》2017年第1期11-14,共4页Practical Pharmacy and Clinical Remedies

基　　金：连云港市科技基金(A1302-31)

摘　　要：目的探讨蛇床子素对肾脏缺血-再灌注损伤(Renal ischemia reperfusion injury,IRI)的作用及其机制。方法通过夹闭左侧肾蒂并切除右肾的方法构建大鼠IRI模型。观察各组尿素氮(BUN)、血清肌酐(Cr)、肾脏病理形态、肿瘤坏死因子α(TNF-α)、单核细胞趋化蛋白-1(MCP-1)和白细胞介素-6(IL-6)、丙二醛(MDA)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GPx)和超氧化物歧化酶(SOD)的表达,评估蛇床子素对大鼠肾脏缺血-再灌注损伤的作用。结果蛇床子素可增加CAT、GPx和SOD表达,减少Cr、BUN、MDA、TNF-α、M CP-1和IL-6的表达以及肾脏病理形态的改变。结论蛇床子素可通过抑制炎症和氧化应激反应而减轻肾脏缺血-再灌注损伤。Objective To study the effect of osthole on renal ischemia reperfusion injury（IRI） and its potential mechanism.Methods The model of IRI was induced by clamping the left renal pedicles with right nephrectomy.The effect of osthole on IRI was examined by evaluating the BUN,Cr,the morphology of kidney and the expression of TNF-α,IL-6,MCP-1,MDA,CAT,GPx and SOD.Results Osthole could significantly increase the expression of CAT,GPX and SOD while attenuating the morphological change of kidney and the expression of Cr,BUN,MDA,TNF—α,MCP-1 and IL-6.Conclusion Osthole can suppress renal ischemia reperfusion injury by reducing inflammation and oxidative stress

关 键 词：蛇床子素 肾脏缺血-再灌注损伤 炎症 氧化应激 

分 类 号：R285.5[医药卫生—中药学]