羟考酮复合右美托咪定在局麻下甲状腺大部分切除术中的应用  

Application of oxycodone combined with dexmedetomidine in subtotal thyroidectomy under local anesthesia

作　　者：程旭丽[1] 周锦[1] 

机构地区：[1]沈阳军区总医院麻醉科,沈阳110016

出　　处：《实用药物与临床》2017年第1期39-41,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的观察羟考酮复合右美托咪定在局麻下甲状腺大部分切除术中应用的临床效果及安全性。方法选择2016年3-6月在我院局麻下行甲状腺大部分切除术的女性患者78例,年龄18~65岁,随机分为右美托咪定组(C组)、右美托咪定复合羟考酮组(F组),每组39例。观察并记录麻醉前、切皮、游离腺瘤或腺肿、缝合各时点SBP、DBP、HR、SpO_2变化,VAS评分,Ramsay镇静评分及用药后不良反应,如恶心呕吐、呼吸抑制等情况。结果 F组血压、心率变化率及VAS评分低于C组,差异有统计学意义(P<0.05);F组Ramsay镇静评分高于C组,差异有统计学意义(P<0.01);两组头晕、恶心呕吐发生率比较差异无统计学意义(P>0.05)。结论羟考酮复合右美托咪定有良好的镇静、镇痛效果,能安全用于局麻下甲状腺大部分切除术。Objective To observe the clinical efficacy and safety of oxycodone combined with dexmedetomidine in thyroid subtotal resection under local anesthesia.Methods Totally 78 patients underwent thyroid subtotal resection in our hospital from March to June 2016 and they were selected and divided into dexmedetomidine group（group C） and oxycodone combined with dexmedetomidine group（group F）,39 cases in each group.The changes in SBP,DBP,HR,SpO_2,VAS score,Ramsay sedation score and adverse reactions after intravenous medication,such as nausea and vomiting,respiratory depression during anesthesia,skin incision,free thyroid goiter or suture time were observed and recorded.Results The changes rates of lood pressure and heart rate and VAS score were lower in group F than that those of group C（P〈0.05）,and the Ramsay sedation score in group F was higher（P〈0.01）.There was no significant difference in the incidence of dizziness,nausea or vomiting between the two groups（P〉0.05）.Conclusion Oxycodone combined with dexmedetomidine has good sedative and analgesic effect,and it is safe for thyroid resection under local anesthesia.

关 键 词：羟考酮 右美托咪定 甲状腺大部分切除术 

分 类 号：R614[医药卫生—麻醉学]