急性冠脉综合征患者血清ICAM-1、VCAM-1、CD40L含量变化及与中医证型的关系  

Changes of contents of serum ICAM-1,VCAM-1,CD40L and their relationship with TCM syndrome types in patients with acute coronary syndrome

作　　者：马爱玲[1] 陶涛[1] 吴兆增[1] 

机构地区：[1]江苏省连云港市东方医院,江苏连云港222042

出　　处：《现代中西医结合杂志》2017年第4期356-358,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：连云港市卫生局青年科技基金项目(Q1211)

摘　　要：目的探讨急性冠脉综合征(ACS)患者血清细胞间黏附分子-1(ICAM-1)、血管细胞黏附分子-1(VCAM-1)及CD40配体(CD40L)水平变化及与中医辨证分型的关系。方法选择84例ACS患者作为ACS组,根据中医辨证分型标准分为心血瘀阻型、痰浊闭阻型、寒凝心脉型、气滞心胸型、心肾阳虚型、气阴两虚型;选择同期健康体检者20例及稳定型冠心病患者20例作为非ACS组。采用酶联免疫ELISA法测定所有受检者血清ICAM-1、VCAM-1及CD40L水平,比较ACS组与非ACS组间各指标的差异,分析血清ICAM-1、VCAM-1、CD40L水平与中医辨证分型的关系。结果 ACS组血清ICAM-1、VCAM-1、CD40L水平均显著高于非ACS组(P均<0.05)。痰浊闭塞型及心血瘀阻型血清ICAM-1、VCAM-1、CD40L水平均明显高于其他4型(P均<0.05),痰浊闭塞型与心血瘀阻型各指标水平比较差异均无统计学意义(P均>0.05);寒凝心脉型血清ICAM-1水平明显高于气滞心胸型(P<0.05),其他2项指标比较差异均无统计学意义(P均>0.05);气滞心胸型、心肾阳虚型、气阴两虚型血清ICAM-1、VCAM-1、CD40L水平比较差异均无统计学意义(P均>0.05)。结论 ACS患者血清ICAM-1、VCAM-1、CD40L水平明显升高,痰浊闭塞型及心血瘀阻型血清ICAM-1、VCAM-1、CD40L水平更高。Objective It is to study the changes of contents of serum ICAM-1,VCAM-1,CD40 L in acute coronary syndrome（ ACS） patients,and the relationship with TCM syndrome types. Methods Eighty-four patients with ACS were selected as ACS group,and they were divided into six TCM types based on traditional Chinese medicine syndrome differentiation,which were stagnant blood of heart,phlegm stagnant in blood,heart-vessels pathogening by cold,stagnation of chest Qi,heartYang and kidney Yang deficiency,Qi and Yin deficiency. 20 cases of patients with stable coronary heart disease and 20 healthy people were selected as non-ACS group. The levels of serum ICAM-1,VCAM-1,CD40 L were determined by ELISA,the differences in every index were compared between ACS group and non-ACS group,the relationship of serum ICAM-1,VCAM-1,CD40 L with TCM syndrome differentiation were analyzed. Results The levels of serum ICAM-1,VCAM-1,CD40 L in ACS group were higher than that in non-ACS group（ P〈0. 05）. The levels in the patients with stagnant blood of heart,phlegm stagnant in blood were higher than that in the other 4 types（ P〈0. 05）. There was no significant difference between stagnant blood of heart and phlegm stagnant in blood（ P〉0. 05）. The level of serum ICAM-1 in heart-vessels pathogening by cold was higher than that in stagnation of chest Qi（ P〈0. 05）,but there was no significant difference in the other 2 indexes between the two types（ P〉0. 05）. There was no significant difference in the content of serum ICAM-1,VCAM-1,CD40 L among stagnation of chest Qi,heart-Yang and kidney Yang deficiency,Qi and Yin deficiency. Conclusion The contents of serum ICAM-1,VCAM-1,CD40 L in ACS patients are significantly increased,and the levels of serum ICAM-1,VCAM-1,CD40 L are higher in the patients with stagnant blood of heart and phlegm stagnant in blood.

关 键 词：细胞间黏附分子-1 血管细胞黏附分子-1 急性冠脉综合征 中医证型 

分 类 号：R541.4[医药卫生—心血管疾病]