TGF-β2、TGFβRⅡ在妊娠期糖尿病的表达  

Expression of TGF-β2 and TGFβRⅡ in gestational diabetes mellitus

作　　者：杨秀华[1] 郭峰[2] 

机构地区：[1]中国医科大学附属第一医院产科,沈阳110001 [2]中国医科大学附属盛京医院急诊科,沈阳110001

出　　处：《现代妇产科进展》2017年第1期23-25,共3页Progress in Obstetrics and Gynecology

基　　金：国家自然科学基金青年科学基金项目(No:31200730)

摘　　要：目的:通过检测妊娠期糖尿病(GDM)患者胎盘中转化生长因子-β2(TGF-β2)及其受体TGFβRⅡmRNA和蛋白的表达,探讨两者在GDM发生中的作用。方法:实时定量PCR、Western blot和免疫组化方法检测30例GDM产妇和30例正常妊娠产妇胎盘组织中TGF-β2及TGFβRⅡ的表达情况。结果:GDM组胎盘组织中TGF-β2和TGFβRⅡmRNA和蛋白表达水平均显著高于正常妊娠组(P<0.05);GDM组胎盘中TGF-β2和TGFβRⅡ阳性表达率均高于正常妊娠组,差异均有统计学意义(P<0.05)。结论:GDM胎盘组织中TGF-β2及TGFβRⅡ升高可能与GDM发生有关,两者可能成为新的诊断标志物和治疗GDM的靶点。Objective：To investigate the expression and function of transforming growth factor beta-2（ TGF-β2） and transforming growth factor beta receptor 2（ TGFβR Ⅱ） in gestational diabetes mellitus（ GDM）.Methods：The placentas from 30 GDM patients and 30 normal pregnant women were collected.The expressions of TGF-β2 and TGFβRⅡ were detected by real-time PCR,Western blot and immunohistochemistry.Results：The mRNA and protein expressions of TGFβ2 and TGFβR Ⅱ were significantly higher in GDM group than those in control group（ P0.05）.The positive expression levels of TGFβ2 and TGFβRⅡ were significantly higher in GDM than those in control group（ P 0.05）.Conclusions：The up-regulations of TGF-β2and TGFβRⅡ might be associated with the etiology of GDM,TGF-β2 and TGFβRⅡ might be targets of diagnosis and treatment in GDM.

关 键 词：妊娠期糖尿病 转化生长因子 转化生长因子受体 

分 类 号：R714.2[医药卫生—妇产科学]