硫酸镁与硝苯地平联合治疗妊娠期高血压疾病的疗效及安全性  

Efficacy and Safety of Magnesium Sulfate and Nifedipine in Treatment of Pregnancy Induced Hypertension

作　　者：陈瑜[1] 肖劲花 李小群[1] 钟明[1] 

机构地区：[1]深圳市宝安区妇幼保健院药剂科,广东深圳518101 [2]深圳市宝安区妇幼保健院产科,广东深圳518101

出　　处：《中国医院用药评价与分析》2016年第12期1664-1666,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨硫酸镁与硝苯地平联合治疗妊娠期高血压疾病的临床疗效及安全性。方法:选取2013年1月—2015年6月深圳市宝安区妇幼保健院收治的100例妊娠期高血压疾病患者,采用计算机随机分组法分为对照组、观察组,每组各50例。对照组患者给予硫酸镁治疗,观察组患者给予硫酸镁+硝苯地平治疗,对比观察2组患者的治疗效果和不良反应发生情况。结果:观察组患者妊娠不良结局发生率为10%(5/50),明显低于对照组的26%(13/50),差异有统计学意义(P<0.05)。观察组新生儿平均1、5 min Apgar评分分别为(7.89±1.25)分、(8.45±1.69),均明显高于对照组的(7.03±1.12)、(7.56±1.55)分,差异均有统计学意义(P<0.05)。治疗后,2组患者收缩压、舒张压、24 h尿蛋白均较治疗前明显降低,且观察组患者明显优于对照组,差异均有统计学意义(P<0.05)。2组患者不良反应发生率均较低,组间差异无统计学意义(P>0.05)。结论:采用硫酸镁与硝苯地平联合治疗妊娠期高血压疾病患者,具有显著的降血压效果,还能有效改善母婴结局,安全性较高。OBJECTIVE： To study the efficacy and safety of magnesium sulfate and nifedipine in treatment of pregnancy induced hypertension. METHODS： 100 patients with pregnancy induced hypertension admitted into Shenzhen City Maternal and Child Health Hospital of Bao＇an District from Jan. 2013 to Jun. 2015 were selected to bedivided into observation group and control group via taking computer random grouping method,with 50 cases in each.The control group were treated with magnesium sulfate,while the observation group received magnesium sulfate and nifedipine. The treatment effects and incidence of adverse drug reactions of two groups were observed and compared.RESULTS： The incidence of pregnancy adverse outcomes in observation group was 10%（ 5 /50）,significantly lower than that of control group [26%（ 13 /50） ],with statistically significant difference（ P〈0. 05）. The Apgar 1 min score and Apgar 5 min score of observation group were respectively（ 7. 89 ± 1. 25） scores and（ 8. 45 ± 1. 69） scores,significantly higher than those of control group [（ 7. 03 ± 1. 12） scores and（ 7. 56 ± 1. 55） scores],with statistically significant difference（ P〈0. 05）. Compared with before treatment,the systolic blood pressure,diastolic blood pressure,24 hour urinary protein of two groups after treatment were significantly decreased,and the observation group was better than the control group,with statistically significant difference（ P〈0. 05）. The incidence of adverse drug reactions in two groups was relatively low,and there was no statistically significant difference between two groups（ P〉0. 05）. CONCLUSINS： Magnesium sulfate and nifedipine in treatment of pregnancy induced hypertension have obvious effects of lowering blood pressure and can effectively improve the pregnancy outcomes with high security.

关 键 词：妊娠期高血压疾病 硫酸镁 硝苯地平 安全性 

分 类 号：R972.4[医药卫生—药品]