鬼臼类中药及其木脂素类成分的药效学研究  

Study on pharmacodynamics of Chinese herbal drug Guijiu and its lignan

作　　者：尚明英[1] 徐珞珊[2] 李萍[2] 徐国钧[2] 王佾先 蔡少青[1] 

机构地区：[1]北京大学药学院天然药物学系,北京100083 [2]中国药科大学,江苏南京210009 [3]江苏省肿瘤研究所,江苏南京210009

出　　处：《中草药》2002年第8期722-724,共3页Chinese Traditional and Herbal Drugs

基　　金：国家"八五"攻关项目 (No.85 -92 0 -0 1-0 1)

摘　　要：目的　研究小叶莲、桃儿七、秕鳞八角莲提取物及鬼臼类中药主要成分鬼臼毒素、去氧鬼臼毒素的抗肿瘤作用。方法　以移植性肝癌及艾氏腹水癌小鼠为实验动物 ,ig给予上述样品 ,分别观察各样品的抗肿瘤作用。结果桃儿七、秕鳞八角莲提取物具有较强的抗肿瘤活性。结论　 5种样品均有抗肿瘤活性。Object To study the antitumor effects of extracts from the fruits, roots and rhizomes of Sinopodophyllum emodi (Wall.) Ying, the roots and rhizomes of Dysosma furfuracea S.Y. Bao and the podophyllotoxin, deoxypodophyllotoxin of Guijiu plants in mice. Methods Tumor borne mice with transplanted HepA and Ehrlich ascites carcinoma (EAC) were used to observe the antitumor and the liver protective effects of the above five samples, which were given orally. Results Extracts of roots and rhizomes of S. emodi, and D. furfuracea showed the significant antitumor effects. Conclusion All the five samples have antitumor activity.

关 键 词：鬼臼类中药 木脂素 药效学 抗肿瘤活性 

分 类 号：R286.91[医药卫生—中药学] R285.1[医药卫生—中医学]