供肝补体C7基因多态性预测肝移植后早期细菌感染的临床研究  

Prediction of early bacterial infection after liver transplantation by donor complement factor component 7 polymorphism

作　　者：张鑫[1] 王普森 李浩[1] 史宝洁 阙伟涛 王春光[1] 钟林[1] 

机构地区：[1]上海交通大学附属第一人民医院普通外科,200080

出　　处：《中华器官移植杂志》2016年第9期525-527,共3页Chinese Journal of Organ Transplantation

摘　　要：目的探讨供肝补体C7基因多态性rs6876739与肝移植后早期受者细菌感染的关系。方法采集2007年7月至2011年1月上海交通大学附属第一人民医院113例肝移植的供肝组织样本，检测C7rs6876739位点的单核苷酸多态性，结合受者的临床资料，分析该位点不同基因型与肝移植术后早期细菌感染的相关性。结果接受C7rs687673基因型为CC的供肝较基因型为TT的供肝，移植后受者更易发生细菌感染（55．6％和26．5％，P=0．021）。多元分析显示，性别（P=0．018）、术前应用广谱抗生素（P=0.001）、住重症监护病房时间（P〈0．001）、气管插管时间≥72h（P=0．031）、二次手术（P=0.045）及胆道并发症（P=0．018）为肝移植后早期细菌感染的独立危险因素。结论供肝C7rs6876739基因多态性与肝移植术后早期细菌感染显著相关。供肝基因型为CC的受者肝移植术后早期细菌感染的风险较TT型者大。Objective To investigate the association between donor complement factor component 7 （C7） rs6876739 gene polymorphisms and risk of early bacterial infection following orthotopic liver transplantation （OLT）. Methods A total of 113 patients who had undergone OLT in Shanghai General Hospital between July 2007 and January 2011 were included. A single nucleotide polymorphism （SNP）, donor C7 rs6876739 was genotyped and analyzed together with clinical data. Results We demortstrated that donor C7 rs6876739 CC genotype had higher risk of early bacterial infection than TT genotype following OLT （55.6% vs. 26. 5%, P = 0. 021）. The multivariate logistic regression analysis revealed that gender （P = 0. 018）, biliary complications （P = 0. 018）, ICU stay after LT （P〈0. 001） and donor C7 rs6876739 genotype （P = 0. 001） were identified as independent factors of early bacterial infection. Conclusion Donor C7 rs6876739 genotype polymorphism is associated with early bacterial infection following OLT and may be a new marker of risk for the development of potentially serious bacterial infection after liver transplantation.

关 键 词：肝移植 细菌感染 补体因子C7 多态性 单核苷酸 

分 类 号：R657.3[医药卫生—外科学]