银杏叶片联合美托洛尔治疗冠心病心力衰竭的临床研究  

Clinical study on Yinxingye Tablets combined with metoprolol in treatment of coronary heart disease with heart failure

作　　者：丁晓云[1] 罗正义[1] 

机构地区：[1]如皋市人民医院心血管内科,江苏如皋226500

出　　处：《现代药物与临床》2016年第12期1917-1920,共4页Drugs & Clinic

摘　　要：目的探讨银杏叶片联合美托洛尔治疗冠心病心力衰竭患者的临床效果。方法选取2013年9月—2016年1月如皋市人民医院收治的冠心病心力衰竭患者90例,随机分为对照组和治疗组,每组各45例。对照组患者在常规治疗基础上口服酒石酸美托洛尔控释片,2次/d,起始剂量为6.25 mg/d,1-2周后每天增加6.25 mg,逐步增至25-75 mg/d。治疗组在对照组的基础上口服银杏叶片,1片/次,3次/d。两组患者连续治疗3个月。评价两组临床疗效,同时比较两组患者心功能、超敏C反应蛋白（hs-CRP）和脑钠肽（BNP）水平改善情况。结果治疗后,对照组和治疗组的总有效率分别为71.11%和86.67%,两组总有效率比较差异具有统计学意义（P〈0.05）。治疗后,两组患者左心室舒张末期内径（LVEDD）和左室收缩末内径（LVESD）均明显降低,同时左心射血分数（LVEF）显著升高,同组治疗前后差异具有统计学意义（P〈0.05）;与对照组相比,治疗后治疗组上述心功能指标显著优于对照组,差异具有统计学意义（P〈0.05）。治疗后,两组患者血清hs-CRP和BNP水平均显著下降（P〈0.05）;且治疗后治疗组血清hs-CRP和BNP水平改善更显著（P〈0.05）。结论银杏叶片联合美托洛尔治疗冠心病心力衰竭患者效果显著,具有一定的临床推广应用价值。Objective To explore the clinical effect of Yinxingye Tablets combined with metoprolol in treatment of coronary heart disease with heart failure. Methods Patients （90 cases） with coronary heart disease with heart failure in the People＇s Hospital of Rugao from September 2013 to January 2016 were randomly divided into the control and treatment groups, and each group had 45 cases. The patients in the control group were po administered with Metoprolol Tartrate Controlled-release Tablets on the basis of conventional treatment, twice daily, the initial dosage was 6.25 mg/d, and increased by 6.25 mg per day after 1 - 2 weeks, gradually to 25 - 75 mg/d. The patients in the treatment group were po administered with Yinxingye Tablets on the basis of the control group, 1 tablet/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and the improvement of heart function, hs-CRP and BNP levels in two groups was compared. Results After treatment, the clinical efficacy in the control and treatment group was 71.11% and 86.67%, respectively, and there were differences between two groups （P 〈 0.05）. After treatment, LVEDD and LVESD in two groups were significantly decreased, at the same time, LVEF was significantly increased, and the difference was statistically significant in the same group （P 〈 0.05）. And these heart function indicators in the treatment group were better than those in the control group, with significant difference between two groups （P 〈 0.05）. After treatment, hs-CRP and BNP in two groups were significantly decreased （P 〈 0.05）. And the hs-CRP and BNP levels in the treatment group were decreased more obviously than those in the control group （P 〈 0.05）. Conclusion Yinxingye Tablets combined with metoprolol has a significant clinical effect in treatment of coronary heart disease patients with heart failure, which has a certain clinical application value.

关 键 词：银杏叶片 酒石酸美托洛尔控释片 冠心病 心力衰竭 左心室舒张末期内径 左室收缩末内径 脑钠肽 

分 类 号：R972[医药卫生—药品]