应用^(13)N-NH_3 PET动态显像诊断垂体疾病  

The preliminary results of the diagnosis of pituitary diseases using^(13)N-NH_3 PET dynamic imaging

作　　者：张祥松[1] 陈红梅[2] 杨华章[2] 唐安戊[1] 乔穗宪[1] 

机构地区：[1]广东省人民医院核医学科PET中心,广州510080 [2]广东省人民医院内分泌科,广州510080

出　　处：《中华核医学杂志》2002年第4期209-210,I002,共3页Chinese Journal of Nuclear Medicine

摘　　要：目的　探讨1 3N NH3PET动态显像诊断垂体疾病的价值。方法　 2例垂体微腺瘤和 1例产后腺垂体功能减退症患者 ,均经MRI、血液内分泌激素测定、临床表现等确诊 ,进行1 3N NH3PET动态显像 ,获得时间 放射性曲线 ,并进行半定量分析。结果　1 3N NH3PET动态显像 ,2例垂体微腺瘤患者垂体显像时间延迟 ,分别在颈内动脉显像后 2 0和 30s时开始显像 ;垂体形态均异常 ,垂体上缘膨隆 ,垂体高度 (矢状面 )分别为 1 75和 1 6 2cm ;垂体平均标准摄取值 (SUV)分别为 3 96和 3 2 8,与丘脑放射性比值分别为 1 5 8和 1 2 7。 1例产后腺垂体功能减退症患者垂体缩小 (0 82cm× 0 83cm× 1 0 3cm) ,显像时间明显延迟 ,在颈内动脉显像后约 3min垂体开始显像 ,垂体时间 放射性曲线低平 ;SUV值为 1 4 8,与丘脑放射性比值为 0 6 4。结论　1 3NObjective To preliminarily evaluate the value of 13 N NH 3 PET dynamic imaging for the diagnosis of pituitary diseases. Methods The 13 N NH 3 PET dynamic imaging was performed on 2 patients with pituitary microadenoma and one patient with hypopituitarism, the diagnoses were confirmed by MRI, levels of relative endocrine hormones in blood and clinical presentations. Results In 2 patients with pituitary microadenoma, the pituitaries were seen in 20 and 30 s after the internal carotid was seen in the dynamic PET images, the upper margins of pituitaries were convex, the heights were 1.75 cm and 1.62 cm, the standard uptake values (SUVs) of pituitaries were 3.96 and 3.28, and the radioactivity ratio of pituitary to thalamus were 1.58 and 1.27. In the patient with hypopituitarism, the pituitary was seen at 3 min after the image of the internal carotid , the image of pituitary was smaller than the normal ones (0.82 cm×0.83 cm×1.03 cm), the SUV of pituitary was 1.48, and the radioactivity ratio of pituitary to thalamus was 0.64. Conclusion The 13 N NH 3 PET dynamic imaging is useful in diagnosing pituitary microadenoma and hypopituitarism.

关 键 词：^13N-NH3 PET动态显像 诊断 垂体疾病 

分 类 号：R817[医药卫生—影像医学与核医学]