经大网膜生物支架胰岛移植技术的探讨  

Study of omentum intraomental bio-scaffold islet transplantation

作　　者：王树森[1,2,3] 裴广辉[1] 王金山[1] 刘尧娟[2] 张博雅[1] 邹家琦 刘蕾[1] 淮明生[1] 张雅敏[1] 杨涛[1] 王智平[1] 郑虹[1] Xiumin Xu Camillo Ricordi 沈中阳[1,2,3] Wang Shnsen Pei G uanghuil Wang Jinshan Liu Yaojuan Zhang Boya Zou Jiaqi Liu Lei Huai Mingsheng Zhang Yamin Yang Tao Wang ZhipingI Zheng Hong Xiumin Xu Camillo Ricordi Shen Zhongyang(Organ Transplantation Center, Tianjin First Central Hospital, Tianjin 300192, China Key Laboratory for Critical Care Medicine of Ministry of Health, Tianjin 300100, China Tianjin Key Laboratory of Organ Transplantation, Tianjin 300192, China #. Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, F)

机构地区：[1]天津市第一中心医院器官移植中心,天津300192 [2]卫生部危重病急救医学重点实验室,天津300100 [3]天津市器官移植重点实验室,天津300192 [4]Diabetes Research Institute,University of Miami Miller School of Medicine,Miami,FL

出　　处：《实用器官移植电子杂志》2016年第6期378-380,共3页Practical Journal of Organ Transplantation(Electronic Version)

基　　金：国家临床重点专科项目(2013544);天津市自然科学基金项目(13JCYBJC42600);公益性行业科研专项(201302009);留学回国人员科研启动基金项目(730-BE034231)

摘　　要：目的探讨临床大网膜胰岛移植途径的效力。方法2例1型糖尿病(type 1 diabetes mellitus,T1DM)患者,顺利完成胰腺修整、胰岛提取等过程后,借助腹腔镜方式,利用可吸收血浆凝血酶为生物支架,完成大网膜胰岛移植术。结果2例患者术后恢复顺利,血糖水平控制平稳、C-肽水平较移植前显著升高,糖化血红蛋白水平较前下降。结论胰岛移植是目前有希望治疗T1DM的方法之一,我们将胰岛移植到大网膜显示经大网膜生物支架胰岛移植术为T1DM患者提供了可行性技术路径。Objective To explore the effectiveness of the omentum islet transplantation procedure.Methods Two patients with type 1 diabetes mellitus（T1DM） were transplanted with islet isolated by laparoscopic approach,resorbable plasma-thrombin as the biologic scaffold in this procedure.Results Two recipients recovered smoothly after islet transplantation,the level of blood glucose was stable,the level of C- peptide was significantly higher than pre-transplantation,and the hemoglobin A1 c level was decreased 2 month after islet tr ansplantation.Conclusions Islet transplantation is currently one of the promising methods of treatment of T1 DM,we transplanted islets to the greater omentum,and the result showed that the procedure of omentum biological scaffold islet transplantation for T1 DM patients provided a feasible technique route.

关 键 词：胰岛移植 1型糖尿病 大网膜 

分 类 号：R657.5[医药卫生—外科学]