血清MFG-E8在预估糖代谢异常患者冠状动脉钙化中的临床价值  

Clinical value of MFG-E8 in the prognosis evaluation of coronary artery calcification in patients with abnormal glucose metabolism

作　　者：王冰[1] 黄陵生[1] 李良海[1] 李梦秋[1] 金平[1] 

机构地区：[1]荆州市中心医院重症医学科,湖北荆州434020

出　　处：《临床急诊杂志》2016年第12期935-937,941,共4页Journal of Clinical Emergency

摘　　要：目的:检测不同糖代谢状态患者MFG-E8的水平,探讨其预估冠状动脉钙化的临床价值。方法:选取2014-01-2015-12住院患者92例,包括正常对照组(Control组,n=28)、糖耐量异常组(IGT组,n=30)和糖尿病组(DM组,n=34)。然后检测各组患者MFG-E8和炎性因子hs-CRP、IL-6的水平,采用64排螺旋CT检测冠状动脉钙化积分,从而评估MFG-E8与冠状动脉钙化程度的相关性。结果:3组患者之间血清炎性因子hs-CRP、IL-6及MFG-E8水平均差异有统计学意义(P<0.05);伴随血清MFG-E8水平的升高,炎性因子hs-CRP、IL-6的水平逐渐降低,冠状动脉钙化积分值也逐渐降低,呈负相关关系(P<0.05)。结论:血清MFG-E8水平与冠状动脉钙化积分呈负相关,提示检测血清MFG-E8可能成为预测糖代谢异常患者发生冠状动脉疾病的重要指标之一。Objective：To explore the clinical value in the prognosis evaluation of coronary artery calcification,the level of MFG-E8 in patients with different glucose metabolism status was detected.Method：Ninety-two hospitalized patients from January 2014 to December 2015 were divided into normal control group（Control group,n=28）,impaired glucose tolerance group（IGT group,n=30）and diabetes group（DM group,n=34）.All patients were detected with the level of MFG-E8 and inflammatory factors hs-CRP and IL-6.Coronary artery calcium score was measured by 64 row helical CT,and then used to assess the correlation between MFG-E8 and coronary artery calcification.Result：With their increase,the levels of inflammatory factors hs-CRP and IL-6,and coronary artery calcium score were decreased gradually（P〈0.05）.Conclusion：Serum MFG-E8 level was negatively related to coronary artery calcium score.It indicated that detection of MFG-E8 could be used to predict the occurrence of coronary artery disease in different glucose metabolism status patients.

关 键 词：乳脂肪球表皮生长因子Ⅷ 冠状动脉钙化 糖尿病 

分 类 号：R541[医药卫生—心血管疾病]