2015年北京大学人民医院万古霉素血药浓度监测分析  

Serum concentration monitoring and analysis of vancomycin at 2015 in Peking University People's Hospital

作　　者：于泽[1] 刘刚[1] 赵海艳[1] 丁庆明[1] 冯婉玉[1] 

机构地区：[1]北京大学人民医院药剂科,北京100044

出　　处：《临床药物治疗杂志》2016年第6期27-29,共3页Clinical Medication Journal

基　　金：国家科技重大专项重大新药创制项目资助(2012ZX09303019)

摘　　要：目的:分析北京大学人民医院2015年万古霉素血药浓度监测情况,为临床个体化用药提供依据。方法:对进行万古霉素血药浓度监测的149例患者的一般资料、原患疾病、病原学检测结果、血药浓度、肾功能等临床资料进行统计分析。结果:患者万古霉素血药浓度监测率为13.26%,万古霉素血药谷浓度在10~20μg·m L^(-1)的患者占41.23%,治疗前后肾功能异常占比率分别为27.52%和30.87%。结论:北京大学人民医院万古霉素血药谷浓度总体正常,但仍有少部分患者血药浓度异常,可结合临床实际适当调整万古霉素用量。Objective： To analyze therapeutic drug monitoring of vancomycin in our hospital at 2015, and to provide evidence for clinical individualized medication. Methods： Statistical analysis was conducted on general information, original illness, pathogen detection result, plasma concentration and renal function which derived from 149 cases of patients with blood concentration monitoring of vancomycin. Results： The therapeutic drug monitoring rate was 13.26%. The blood trough concentration during 10-20 μg·m L^（-1） accounted for 41.23%. Before and after treatment renal dysfunction rate were 27.52% and 30.87% respectively. Conclusion： Vancomycin therapeutic drug monitoring results were mainly normal in most of our patients our hospital, but there were still some aberrant testing results. The dosage of vancomycin should be adjusted according to clinical reality.

关 键 词：万古霉素 血药浓度 监测 

分 类 号：R969.3[医药卫生—药理学]