血透患者应用多联抗癫痫药物治疗抽搐1例  

A case of seizure treated with multiple antiepileptic therapy under dialysis

作　　者：邹羽真[1] 杜小莉[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院药剂科,北京100730

出　　处：《临床药物治疗杂志》2016年第6期78-80,共3页Clinical Medication Journal

摘　　要：目的:探讨血液透析患者应用多联抗癫痫药物治疗难治性抽搐过程中的给药方案,学习抗癫痫药物血药浓度检测值的解读。方法:以治疗药物监测和透析药物代谢动力学知识分析1例血液透析患者应用多联抗癫痫药物的治疗过程,并对患者用药的有效性和安全性进行监护。结果:合理解读血药浓度检测值,对于解释患者病情变化的原因、提高药物疗效和减少不良反应均有意义,通过药学专业知识的支持,难治性抽搐得到控制,并优化了给药方案。结论:对于血透患者的多联抗癫痫药物治疗,应当结合血药浓度监测,关注药物不良反应,运用血液透析的药物代谢动力学和药物相互作用进行合理解读,制定个体化给药方案。Objective： To explore the dosage regimen of multiple antiepileptic therapy for patients with refractory seizure under regular dialysis and to study interpreting plasma concentration values. Methods： The therapeutic process of one case of refractory seizure under regular dialysis was analyzed with applying professional knowledge of therapeutic drug monitoring（TDM） and dialysis pharmacokinetic profile. Results： TDM help interpret clinical effects, improve drug efficacy, and reduce drug side effects Supported by the pharmaceutical professional knowledge, refractory seizure was controlled and the regimen was optimized. Conclusion： For patients receiving multiple-antiepileptic therapy under peritoneal dialysis, an individualized dosage regimen should be made by analyzing dialysis pharmacokinetic and drug interaction according to TDM, besides paying carefully attention to drug side effects.

关 键 词：血液透析 治疗药物监测 抗癫痫药物 抽搐 

分 类 号：R971.6[医药卫生—药品]