A new bisbenzylisoquinoline alkaloid from Plumulanelumbinis  

作　　者：Xiao-Xiao Zhang Shuang-ChengMa Peng Mao Ya-Dan Wang 

机构地区：[1]Beijing University of Chinese Medicine, Beijing 100029, China [2]National Institutes for Food and Drug Control, Beijing 100050, China [3]Shaanxi Momentum Pharmaceutical Co., LTD, Xi'an 710075, China

出　　处：《Chinese Chemical Letters》2016年第12期1755-1758,共4页中国化学快报（英文版）

基　　金：financially supported by 12th Five-Year Plan Major New Drug Discovery Science and Technology Projects for support of this research (No.2014ZX09304307-002)

摘　　要：One new bisbenzylisoquinoline alkaloid, neferine N-oxide （1）, along with three known compounds, neferine （2）, liensinine （3）, and isoliensinine （4）, were isolated from Plumulanelumbinis - the embryo of the seed of Nelumbonucifera. Their structures were elucidated by extensive spectroscopic analysis （MS, UV, IR, NMR）, and the absolute configurations were determined by experimental circulardichroism （CD） spectra. Compound 1 is a new naturally occurring bisbenzylisoquinoline alkaloid with an N-oxide functionality, and the CD spectrum of （1R, 1＇R） neferine is first reported. The antioxidant activities of compounds 1-4 were evaluated using the ORAC assay, which illustrated that all these compounds showed the different levels of oxygen radical absorbance capacity.One new bisbenzylisoquinoline alkaloid, neferine N-oxide （1）, along with three known compounds, neferine （2）, liensinine （3）, and isoliensinine （4）, were isolated from Plumulanelumbinis - the embryo of the seed of Nelumbonucifera. Their structures were elucidated by extensive spectroscopic analysis （MS, UV, IR, NMR）, and the absolute configurations were determined by experimental circulardichroism （CD） spectra. Compound 1 is a new naturally occurring bisbenzylisoquinoline alkaloid with an N-oxide functionality, and the CD spectrum of （1R, 1＇R） neferine is first reported. The antioxidant activities of compounds 1-4 were evaluated using the ORAC assay, which illustrated that all these compounds showed the different levels of oxygen radical absorbance capacity.

关 键 词：Plumulanelumbinis Bisbenzylisoquinoline alkaloid Neferine N-oxide ORAC assay Antioxidative activity 

分 类 号：O629.33[理学—有机化学]