帕米膦酸二钠治疗绝经后骨质疏松瘀血症的近期研究  

Resently Study on Treatment of Postmenopausal osteoporosis with Blood Stasis by Pamidronate Disodim

作　　者：盘荣贵[1] 文婉臣 韩杰[1] 覃杰[1] 樊丽霞[3] 滕居赞[1] 

机构地区：[1]广西中医药大学附属瑞康医院骨关节与运动医学科,广西南宁530000 [2]广西中医药大学附属瑞康医院预防免疫科,广西南宁530000 [3]广西中医药大学研究生院,广西南宁530000

出　　处：《吉林医学》2016年第12期2870-2873,共4页Jilin Medical Journal

基　　金：广西卫生与计划生育委员会计划课题[课题编号:Z2015427]

摘　　要：目的:探讨帕米膦酸二钠治疗绝经后骨质疏松淤血症临床疗效及机制。方法:将50例患者随机分为两组(观察组、对照组),治疗在首月、次月、第3月大致相同时段门诊实施。观察组静脉滴注帕米膦酸二钠葡萄糖注射液30 mg/d,连续3 d,90 mg/月,连续3月,同时每天口服钙剂和活性维生素D。对照组静脉滴注等量葡萄糖注射液也同时口服钙剂及活性维生素D。每例患者分别在治疗前、第3月治疗后3天,进行疼痛评分、舌象变化评分、甲皱微循环、血液流变学检查评估。结果:观察组治疗后疼痛评分、舌象变化评分较治疗前显著降低;甲皱微循环、血液流变较治疗前显著改善,前后比较差异有统计学意义(P<0.01)。结论:帕米膦酸二钠可以显著缓解绝经后骨质疏松血瘀症疼痛,改善淤血情况,这可能由于帕米膦酸二钠降低患者骨转换生物标记物水平;升高诸如NO、ET和前列腺素合成酶等血管活性物质有关。Objective To study the efficacy and mechanisms on Treatment of Postme - nopausal osteoporosis with Blood Stasis by Pamidronate Disodim. Method 50 patients were divided into observation group and control group randomly;The treatment were separately practiced in Clinic at the roughly same time in first,second and third month. The patients in observation group reeeived 30 mg Pamidronate Disodim by intravenous drip daily and 90 mg in 3 days continuously per month and 270 mg in 3 months continuously and Oral aetive vitamin D and calcium meanwhile. The patients in control group received identical dose of Glucose Injection,aetive vitamin D and e.aleium by the same way. To study the pain seore ,Tongue Pieture ,nail fold microcireulation ,Hemorheology of eaeh patient at before and the third day after Treatment. Results The pain score ,Tongue Picture score of observation group were deereased significantly, there was nail fold microcireulation, Hemorheology of observation group were decreased significantly showed signifieant differenee between Before and After（ P 〈 0.01 ）. Conclusion The Pamidronate Diso -dim eould effectively relieve pain in patients on Postmenopausal osteoporosis with Blood Stasis and improved Blood Stasis as that was associated with decreasing levels of bone turnover markers and increased vasoaetive substanees such as NO ,ET and Prostaglandin Synthetase.

关 键 词：帕米膦酸二钠 绝经后骨质疏松 淤血 机制 

分 类 号：R580[医药卫生—内分泌]