联合检测血清降钙素原与C反应蛋白在小儿肺炎诊断中的应用  

Application of combined detection of serum procalcitonin and C-Reactive protein levels in diagnosis of pediatric pneumonia.

作　　者：王永珍[1] 吴元健[1] 金一[1] WANG Yong-zhen WU Yuan-jian JIN Yi(Department of Clinical Laboratory, the Headquater of Municipal Hospital Affilicated to Nanjing Medical College, Jiangsu Suzhou 215002)

机构地区：[1]南京医科大学附属苏州市立医院本部检验科,江苏苏州215002

出　　处：《医学检验与临床》2016年第8期38-40,共3页Medical Laboratory Science and Clinics

摘　　要：目的：探讨联合检测血清降钙素原和C反应蛋白在小儿肺炎定性诊断中的临床意义。方法：回顾性分析本院50例确诊为细菌性肺炎（28例）和病毒性肺炎（22例）患儿的临床资料，探讨患儿血清降钙素原和C反应蛋白水平与患儿肺炎病原学之间的联系。以上病例均经我院实验室病原学检查及血清学检查等临床实验确诊。结果：细菌性肺炎组的血清降钙素原、C反应蛋白水平分别为（2．87±0．043）ng／ml、（17．49±9．57）mg／L；病毒性肺炎组血清降钙素原、C反应蛋白水平分别为（0．41±0．19）ng／ml、（13．34±8．26）mg／L；细菌性肺炎组的血清降钙素原、C反应蛋白水平分别高于病毒性肺炎组，差异有统计学意义（P〈0．05）。细菌性肺炎组的PCT、CRP检测阳性率分别为92．9％、57．1％，均高于病毒性肺炎组；PCT指标诊断细菌性肺炎的特异性、灵敏度均高于CRP指标；差异有统计学意义（P〈0．05）。结论：血清降钙素原和C反应蛋白水平在小儿细菌性肺炎中均有所升高；血清降钙素原和C反应蛋白的联合检测，可判断小儿肺炎的病原学种类；PCT指标诊断细菌性肺炎较CRP指标具有更高的特异性、灵敏度。Objective： To investigate the application of combined detection of serum procalcitonin （PCT） and C-reactive protein （CRP） in the diagnosis of Pediatric pneumonia. Methods： A retrospective analysis was designed to explore the relationship of serum procalcitonin （PCT） and C-reactive protein （CRP） levels with the type of children pneumonia. All the 50 cases （bacterial infection group, n=28; virus infection group, n=22） were confirmed by pathogenic and serologic examination in our clinical laboratory. Results： The PCT, CRP levels of bacterial infection group were （2.87±0.043） ng/ml, （17.49±9.57） mg/L respectively. The PCT, CRP levels of virus infection group were （0.41±0.19） ng/m], （13.34±8.26） mg/L respectively, The levels of PCT, CRP in bacterial infection group were significantly higher than that of virus infection group and had statistically significant difference （P〈0.05） . The positive rates of PCT and CRP in the bacterial infection group were 92.9% and 71.4%. The specificity and sensitivity of PCT was higher than that of CRP in bacterial infection group. These differences all had statistical significance （P〈0.05） .Conclusion： The serum procalcitonin （PCT） and C-reactive protein （CRP） had certain values in identifying bacterial infection and virus infection. PCT had a good value for the identification of bacterial infections. Combined detection of PCT and CRP showed important significance in differential diagnosis of the type of children pneumonia.

关 键 词：小儿肺炎 血清降钙素原 C反应蛋白 

分 类 号：R51[医药卫生—内科学]