Adsorption equilibrium for Z-ligustilide on C18-bonded silica from supercritical carbon dioxide  

作　　者：Huisheng Lü Shuangyan Liu Yonghui Li Fanmei Meng Dawei Yao Xufei Mo 

机构地区：[1]Key Laboratory for Green Chemical Technology of Ministry of Education, Tianjin University R&D Center for Petrochemical Technology

出　　处：《Chinese Journal of Chemical Engineering》2016年第12期1680-1686,共7页中国化学工程学报（英文版）

摘　　要：Adsorption equilibrium is of great importance for the preparative supercritical fluid chromatography(pre-SFC) in defining supercritical adsorption behavior and the industrial amplification.This paper presents adsorption isotherms of Z-ligustilide from supercritical carbon dioxide(SC-CO_2) on C18-bonded silica.Adsorption behavior was studied at 305.15 K,313.15 K and 323.15 K with SC-CO_2 density varying from 0.687 g·cm^(-3) to0.863 g·cm^(-3) with the elution by characteristic points(ECP) method.The adsorption amount of Z-ligustilide from SC-CO_2 on C18-bonded silica decreased with the increasing density of the mobile phase as well as the increasing temperature.Adsorption equilibrium data were fitted by Langmuir and Freundlich isotherm models,and the Langmuir isotherm model performed better for describing the whole adsorption process on the column.The monolayer saturation adsorption capacity of Z-ligustilide is in the range of 3.0 × 10^(-4) mg·cm^(-3) to5.5 × 10^(-4) mg·cm^(-3) with an average value of 4.0 × 10^(-4) mg·cm^(-3).Adsorption equilibrium is of great importance for the preparative supercritical fluid chromatography（pre-SFC） in defining supercritical adsorption behavior and the industrial amplification.This paper presents adsorption isotherms of Z-ligustilide from supercritical carbon dioxide（SC-CO_2） on C18-bonded silica.Adsorption behavior was studied at 305.15 K,313.15 K and 323.15 K with SC-CO_2 density varying from 0.687 g·cm^（-3） to0.863 g·cm^（-3） with the elution by characteristic points（ECP） method.The adsorption amount of Z-ligustilide from SC-CO_2 on C18-bonded silica decreased with the increasing density of the mobile phase as well as the increasing temperature.Adsorption equilibrium data were fitted by Langmuir and Freundlich isotherm models,and the Langmuir isotherm model performed better for describing the whole adsorption process on the column.The monolayer saturation adsorption capacity of Z-ligustilide is in the range of 3.0 × 10^（-4） mg·cm^（-3） to5.5 × 10^（-4） mg·cm^（-3） with an average value of 4.0 × 10^（-4） mg·cm^（-3）.

关 键 词：Z-ligustilide C18-bonded silica Pre-SFC Adsorption equilibrium Isotherm model 

分 类 号：R284[医药卫生—中药学] O647.3[医药卫生—中医学]