rt-PA联合牛黄熄风胶囊治疗急性脑梗死临床研究  

Clinical Study of rt-PA Combined with Niuhuang Xifeng Capsule in Treatment of Acute Cerebral Infarction

作　　者：李晓慧[1] 张伦忠[2] 

机构地区：[1]潍坊医学院神经病学教研室,山东潍坊261053 [2]潍坊市中医院中风科

出　　处：《潍坊医学院学报》2016年第6期412-414,共3页Acta Academiae Medicinae Weifang

摘　　要：目的观察牛黄熄风胶囊对经阿替普酶(rt-PA)静脉溶栓后的急性脑梗死疗效的影响,初步探讨其治疗急性脑梗死的不良反应。方法分析30例牛黄熄风胶囊治疗经rt-PA静脉溶栓后的急性脑梗死患者的临床资料,评价患者溶栓后24h,3个月后的临床疗效。根据美国国立卫生院卒中量表(NIHSS评分)及改良Rank量表(mRS评分)评价神经功能恢复情况及预后,同时通过观察安全性指标评价牛黄熄风胶囊对肝功、肾功的影响。结果治疗后神经功能缺损恢复良好者51例,不良者9例,两组治疗后组间NIHSS评分比较,差异具有显著性(P=0.00)。3个月后随访评价患者mRS评分改善情况,经比较两组治疗后差异具有显著性(P=0.00),同时肝肾功方面未见明显不良影响。结论牛黄熄风胶囊合理应用能改善急性脑梗死治疗的临床效果,并且未见远近期不良影响。Objective To observe the effect of Niuhuang Xifeng capsule in the treatment of the curative effect of rt-PA after intravenous thrombolysis in acute cerebral infarction. Preliminary discussion the adverse reactions of Niuhuang Xifeng capsule in treatment of acute cerebral infarction. Methods Retrospective analysis of 30 cases of Niuhuang Xifeng capsule treated with alteplase in patients with clinical data after intravenous thrombolysis in acute cerebral infarction,evaluation of clinical efficacy of patients with 24 h and 3 months after thrombolysis. According to the National Institutes of Health Stroke Scale（ NIHSS） and modified Rank scale（ mRS） to evaluate the recovery of neurological function and prognosis,at the same time by observing the safety evaluation effect of Niuhuang Xifeng Capsule on liver function and renal function. Results There were 51 cases with good recovery of neurological deficits after treatment. There were 9 cases of poor patients. There was a significant difference in NIHSS scores between the two groups after treatment（ P = 0. 00）. After 3 months follow-up evaluation of patients with mRS score improvement,comparing the two groups after treatment,the difference was significant（ P = 0. 00）,while the liver and kidney function had no significant adverse effects. Conclusion The reasonable application of the clinical effect of Niuhuang Xifeng capsule can improve the treatment of acute cerebral infarction,and no long-term adverse effects.

关 键 词：牛黄熄风胶囊 脑梗死 急性 阿替普酶 

分 类 号：R969.4[医药卫生—药理学]