氨甲环酸应用于成人退变性腰椎侧凸矫形手术的临床研究  

Clinical Study on Application of Tranexamic Acid in Adult Degenerative Lumbar Scoliosis Orthopedic Surgery

作　　者：王胜[1] 邱玉金[1] 刘文华[1] 王明玲[2] 

机构地区：[1]潍坊医学院附属医院脊柱外科,山东潍坊261041 [2]潍坊医学院麻醉学系

出　　处：《潍坊医学院学报》2016年第6期467-469,共3页Acta Academiae Medicinae Weifang

摘　　要：目的探讨成人退变性腰椎侧凸（ALSS）矫形术中静脉应用氨甲环酸对术后失血的有效性及安全性。方法 ALSS矫形手术患者50例随机分为氨甲环酸组（A组）和对照组（B组）,A组患者在手术开始前15-30min输注氨甲环酸的负荷量100mg/kg,维持量为10mg/（kg·h）,至手术结束,B组为对照组,术中给予输注等量等渗盐水。术中观察血红蛋白指导输血,记录术中出血量、术后刀口液体引流量,术中、术后异体血输注情况,术后并发症发生情况。结果与对照组相比,A组术中出血量、输血量、术后刀口液体引流量均降低（P〈0.05）。结论氨甲环酸在ALSS矫形手术可明显减少术中出血量、输血量及刀口液体引流量。Objective To investigate the adult lumbar spine scoliosis surgery intravenous tranexamic acid on postoperative blood loss of efficacy and safety. Methods Adult lumbar spine scoliosis surgery patients were randomly divided into 50 cases of tranexamic acid group（ A group） and control group（ group B）. A group of patients before surgery15 - 30 minute infusion of tranexamic acid loading dose 100 mg / kg,maintenance dose of 10 mg /（ kg·h）,until the end of surgery,group B as a control group,an equal amount of intraoperative administration of isotonic saline infusion. Intraoperative blood transfusion hemoglobin guidance,record blood loss,postoperative incision drainage,postoperative allogeneic blood transfusion,postoperative complications were observed. Results Compared with the control group,the tranexamic acid group blood loss,blood transfusion,postoperative drainage volume were reduced（ P〈0. 05）. Conclusion Tranexamic acid in an adult lumbar spine scoliosis surgery can significantly reduce blood loss,blood transfusion and incision drainage,is safe and effective.

关 键 词：成人退变性腰椎侧凸 氨甲环酸 外科 手术 

分 类 号：R681.5[医药卫生—骨科学]