以肿瘤坏死因子α转基因小鼠为类风湿关节炎模型的研究进展  

A Research Progress on the Rheumatoid Arthritis Model Using TNF Transgenic Mouse

作　　者：王腾腾[1,2] 徐浩[1,2] 王拥军[1,2,3] 施杞[1,2] 梁倩倩[1,2] Wang Tengteng Xu Hao Wang Yongjun Shi Qi Liang Qianqian(Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China Institute of Spine Disease, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China School of Rehabilitation Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China)

机构地区：[1]上海中医药大学附属龙华医院,上海200032 [2]上海中医药大学脊柱病研究所,上海200032 [3]上海中医药大学康复医学院,上海200120

出　　处：《世界科学技术-中医药现代化》2016年第11期1869-1873,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委重点项目(81330085):痰瘀型类风湿性关节炎与淋巴关系的基础研究;负责人:施杞;国家自然科学基金委重大国际合作项目(81220108027):益气祛湿法调控淋巴系统对炎症性关节炎的影响;负责人:王拥军;教育部高等学校全国优秀博士学位论文作者专项资金资助项目(201276):负责人:梁倩倩;上海市龙华医院龙医创新团队(LYCX-01):祛瘀化瘀防治颈痛和炎性关节炎的基础研究;负责人:梁倩倩;上海市卫计委中医药三年行动计划项目(ZY3-CCCX-2-1002):国家中医临床研究基地建设项目;负责人:崔学军;筋骨理论与治法教育部重点实验室;负责人:王拥军;上海市长宁区卫生与计划生育委员会"光华卓越PI工程"项目(2016-01);负责人:施杞

摘　　要：类风湿关节炎(Rheumatoid Arthritis,RA)是一种慢性自身免疫疾病,肿瘤坏死因子α(Tumor Necrosis Factor,TNF-α)过表达在本病的发病过程中起到重要的作用,并介导了多种炎症因子的表达。目前抗TNF药物已广泛应用于RA临床。过表达人TNF-α的转基因小鼠可出现类似RA的病理表现:起病缓慢、发病率高、模型稳定。因此,TNF转基因(TNF-Tg)小鼠模型在RA研究中具有重要的意义,现已广泛应用于RA的诊疗技术和病理机制研究,尤其是淋巴管功能的研究,并取得一系列成果。本文针对该模型小鼠的生理病理特征、研究进展进行综述。Rheumatoid arthritis（RA） was recognized as a chronic and autoimmune disease. The overexpression of tumor necrosis factor alpha（TNF-α） was of great significance in the pathogenesis of RA and mediated the levels of various inflammatory factors. At present, anti-TNF agents were widely used for the treatment of RA in clinic. The genetically modified mice, overexpressing human TNF-α, could appear pathological manifestations being similar to RA with slow onset, high incidence rate and stable occurrence. Therefore, TNF transgenic（TNF-Tg） mouse model was significant in the study, generally applied to the curative and mechanism researches of RA, especially some remarkable and fruitful studies over lymphatic vessels. In this study, we summarized the pathophysiological characteristics of the mouse model based on the current research status.

关 键 词：肿瘤坏死因子Α 转基因小鼠 类风湿关节炎 淋巴 

分 类 号：R274[医药卫生—中医骨伤科学]