支气管鼻病毒感染与哮喘患儿发病的相关性  

The Correlation between Bronchial Rhinovirus Infection and Incidence of Asthma Children

作　　者：熊顺军[1] 王捷荣[1] 王艳军[1] 李慧娟[1] 张小芳[1] XIONG Shun-jun WANG Jie-rong WANG Yan-jun LI Hui-juan ZI-IANG Xiao-fang(Department of Pediatrcs, Zhongnan Hospital of Wuhan University Wuhan, Hubei, 430071, China)

机构地区：[1]武汉大学中南医院儿科,湖北武汉430071

出　　处：《现代生物医学进展》2016年第35期6845-6847,共3页Progress in Modern Biomedicine

摘　　要：目的:探讨支气管鼻病毒感染与哮喘患儿发病的相关性。方法:选择2012年8月至2015年3月在医院治疗的45例哮喘急性发作期患儿为哮喘发作组和45例哮喘缓解期患儿为哮喘缓解组,并选择同期40例健康体检儿童作为正常组;采用PCR法对鼻病毒基因进行检测以判定患儿感染,采用全血细胞分析仪测定外周血嗜酸性粒细胞(EOS)计数,采用化学发光免疫分析仪测定血清总免疫球蛋白E(T-IgE),对T-IgE与EOS进行相关性分析。结果:哮喘发作组鼻病毒感染14例占31.11%,明显高于对照组0例占0.00%和哮喘缓解组3例占6.67%,差异均有统计学意义(P均<0.05),而哮喘缓解组鼻病毒感染率较对照组无明显变化,差异无统计学意义(P>0.05)。哮喘发作组和哮喘缓解组血清T-IgE与EOS明显高于正常组,差异有统计学意义(P<0.05);而哮喘发作组血清T-IgE与EOS明显高于哮喘缓解组,差异有统计学意义(P<0.05)。哮喘发作组鼻病毒感染患儿血清T-IgE与EOS明显高于非鼻病毒感染患儿,差异具有统计学意义(P<0.05)。正常组患儿血清T-IgE与EOS无相关性(r=0.325,P>0.05);哮喘发作组血清T-IgE与EOS正相关性(r=0.736,P<0.05);哮喘缓解组血清T-IgE与EOS正相关性(r=0.613,P<0.05);哮喘发作组鼻病毒感染患儿血清T-IgE与EOS无相关性(r=0.316,P>0.05),非鼻病毒感染患儿血清T-IgE与EOS正相关性(r=0.674,P<0.05)。结论:鼻病毒感染与儿童哮喘的严重程度有关,且患儿的血清T-IgE越高,越容易发生鼻病毒感染,导致哮喘病情加重。Objective： To study The correlation between bronchial rhinovirus infection and incidence of asthma children. Methods： 45 cases of children with asthma acute phase（children asthma group）and 45 cases of children with asthma remission（children asthma relief group）during August 2012 to March 2015 in our hospital treatment were choose, and at the same time 40 cases health children（normal group）were choose. The PCR method was adopted to test the rhinovirus genes to determine the children with infection, whole blood cell analyzer peripheral was determined eosinophil count, immunized with chemiluminescence analyzer was determined total serum immunoglobulin E T, correlation analysis was carded out on the T-IgE and EOS. Results： The rhinovirus infections of children asthma group had 14 cases, accounted for 31.11%, was obviously higher than that of childhood asthma case group（3 cases, accounted for 6.67%） and the normal group（0 case, accounted for 0.00%）, statistically significant difference （P〈0.05）, there were no statistically significant differences for children asthma rhinovirus infection rate between alleviate group and normal group （P〉0.05）; Compared with normal group, T-IgE, EOS of children of asthma and asthma relief group increased obviously, statistically significant difference（P〈0.05）, compared with childhood asthma remission group, T-IgE, EOS of children asthma group increased obviously, statistically significant difference（P〈0.05）; T-IgE, EOS of rhinovirus infection Children were significantly higher than non-rhinovirus infection children, statistically significant difference（P〈0.05）; T-IgE has no correlation with EOS in normal group（r=0.325, P〉0.05）, T-IgE was correlation with EOS in children asthma relief group（r=0.613, P〈0.05）, T-IgE was correlation with EOS in children asthma group（r=0.736, P〈0.05）. In children asthma group, T-IgE had no correlation with EOS in rhinovirus infection children（r=0.316, P〉0.05）, T-IgE was correlatio

关 键 词：哮喘患儿 鼻病毒 感染 相关性 

分 类 号：R562.25[医药卫生—呼吸系统] R725.6[医药卫生—内科学]