烧伤后残余创面外用rhEGF和rhGM-CSF的疗效对比  

Contrast of the Curative Effect of External Use rhEGF and rhGM-CSF for Residual Burn Wounds

作　　者：孟祥海[1] 王晓琳[1] 华振[1] 孙超峰[1] 吕小星[1] 李学拥[1] MENG Xiang-hai WANG Xiao-lin HUA Zhen SUN Chao-feng LV Xiao-xing LI Xue-yong(Department of Burn and Plastic Surgery, The fourth military medical university Tangduhospital, Xi＇an, Shaannxi, 710038, China)

机构地区：[1]第四军医大学唐都医院烧伤整形科,陕西西安710038

出　　处：《现代生物医学进展》2016年第35期6888-6890,共3页Progress in Modern Biomedicine

摘　　要：目的：比较局部应用重组人表皮生长因子（rh EGF）与重组人粒细胞巨噬细胞集落刺激因子（rh GM-CSF）对烧伤后残余创面愈合的影响。方法：选择2013年2月-2015年12月在我院进行诊治的烧伤后残余创面患者80例,采用自体对照的研究方法,每例患者选取2处烧伤后残余创面,随机分为EGF组和GM-CSF组,EGF组采用rh EGF凝胶治疗,GM-CSF组采用rh GM-CSF凝胶治疗。观察用药后的创面愈合时间和愈合率,选择8例患者分别在治疗前和治疗后切取创面边缘组织标本,病理学观察用药后创面组织中成纤维细胞数及毛细血管数。结果：与EGF组相比,GM-CSF组用药治疗7、14 d后创面愈合率明显升高（P〈0.05）;EGF组的创面愈合时间为（16.23±4.15）d,明显长于GM-CSF组的（12.39±2.16）d（P〈0.05）;用药治疗7、14 d后,两组的成纤维细胞数和毛细血管数均明显高于治疗前（P〈0.05）;EGF组的成纤维细胞数和毛细血管数均明显低于GM-CSF组（P〈0.05）。结论：rhGM-CSF比rhEGF更能促进烧伤后残余创面愈合,缩短创面愈合时间,可能与其更能促进成纤维细胞的增殖或迁移,加快毛细血管的生成有关。Objective： To contrast of the curative effect of external use rhEGF and rhGM-CSF for residual burn wounds. Methods： 80 cases of patients with residual bum wounds who were treated in our hospital from January 2013 to December 2015 were selected. Using autologous comparison research method, selected 2 residual burn wounds in each patient, were divided into EGF group and GM-CSF group. EGF group was treated with rhEGF gel, GM-CSF group was treated with rhGM-CSF gel. The wound healing time and healing rate were observed, selected 8 patients for wound edge tissue samples before treatment and after treatment respectively, fiber cell number and capillary number were observed. Results： Compared with the EGF group, after treatment of 7, 14 d, the healing rate of GM-CSF group was increased significantly （P〈0.05）; the wound healing time of EGF group was （16.23 ± 4.15） d, significantly longer than that of GM-CSF group（12.39± 2.16） d （P〈0.05）; after treatment of 7, 14 d, the number of fibroblasts and capillary of the two groups were significantly higher compared with before treatment（P〈0.05）; the number of fibroblasts and capillary of the EGF group were significantly lower that of GM-CSF group（P〈0.05）. Conclusions： Compared with rhEGF, rhGM-CSF can promote residual bum wounds healing, shorten the wound healing time, and promote fibroblasts proliferation or migration, speed up the formation of blood capillary.

关 键 词：烧伤 表皮生长因子 粒细胞巨噬细胞集落刺激因子 创面愈合 

分 类 号：R644[医药卫生—外科学]