江苏妇女高危型HPV感染与宫颈癌及癌前病变相关性研究  

Research of the Relationship between High-risk Human Papillomavirus Infection in Jiangsu Women and Cervical Cancer and Precancerous Lesions

作　　者：张婕妤[1] 封利颖[1] 芮建中[1] 曹晓梅[1] 初亚男[1] ZHANG Jie-yu FENG Li-ying RUI Jian-zhong CAO Xiao-mei CHU Ya-nan(Department of Pharmacology, Nanjing General Hospital of Nanjing Military Command, Nanjing, Jiangsu, 210000, China)

机构地区：[1]南京军区南京总医院药理科,江苏南京210000

出　　处：《现代生物医学进展》2016年第36期7135-7139,共5页Progress in Modern Biomedicine

基　　金：南京军区南京总医院院管课题(2015043)

摘　　要：目的:探讨江苏妇女HR-HPV基因型在正常宫颈、癌前病变(CIN I、CIN II、CIN III)和宫颈癌的分布特点及关系,为宫颈癌预防提供理论依据。方法:对2014年12月至2015年12月在我院行宫颈组织病理检查的424例江苏妇女进行HPV分型检测。以病理检查结果为依据,分为正常组、CIN I组、CIN II组、CIN III组、宫颈癌组,运用卡方检验研究江苏妇女HR-HPV感染与不同宫颈病变组的关系。结果:正常组、CIN I组、CIN II组、CIN III组、宫颈癌组的HR-HPV感染率分别为24.3%、50.0%、71.5%、75.9%、82.1%。正常组与各病变组的感染率有统计学差异(P<0.01)。单一型别和多重型别感染率无差异(P=0.973);随着宫颈病变级别增加,HR-HPV分布不同。CIN I组以HPV16、52、58和51最为常见。CIN II/III组以HPV16、58、52、33和31最为常见。宫颈癌组以HPV16、53、18和58最为常见;HR-HPV感染年龄高峰为>49岁,感染年龄低峰为20-29岁(P<0.01)。结论:江苏妇女宫颈病变的严重程度与HR-HPV感染率呈正相关,与感染HPV高危型的数目无关。除了HPV16,HPV58、52、33和31均与宫颈癌和癌前病变密切相关。HR-HPV感染率存在年龄差异,应加强对>49岁江苏女性的重视,定期进行HPV分型检测和宫颈病变筛查。Objective：To explore the distribution features and relationship between HR-HPV genotypes in Jiangsu women and normal cervix and precancerous lesions （CIN I, CINII, CIN III） and cervical cancer, thus providing theoretical basis for prevention of cervical cancer. Methods： 424 Jiangsu women underwent pathological examination of cervical tissues from December 2014 to December 2015 in our hospital were analyzed by HPV typing detection. They were divided into normal group, CIN I group, CIN II group, CIN III group and cervical cancer group according to the pathological examination results. Chi-square test was applied to study the relationship between HR-HPV infection of Jiangsu women and different cervical lesion groups. Results： The prevalence of high-risk HPV infection in normal group, C1N I group, CIN II group, CIN III group and cervical cancer group were 24.3 %, 50.0 %, 71.5 %, 75.9 % and 82.1%, respectively. There was statistically difference in high-risk HPV prevalence between normal group and four cervical lesion groups （P〈 0.01）. There was no difference between the prevalence of single infection and multiple infection （P=0.973）; the distribution of HR-HPV types in cervical lesion groups differed with the aggravation of the degree of cervical lesions. In CIN I, the common genotypes were HPV 16, 52, 58 and 51. In CIN II/III group, the most common genotypes were HPV 16, 58, 52, 33 and 31. In cervical cancer group, the most common genotypes were HPV 16, 53, 18 and 58. The prevalence of high-risk HPV was found to be highest at the age over 49 years old, and to be lowest at the age of 20-29 （P〈0.01）. Conclusions： The severity of cervical lesions in Jiangsu women was positively correlated with the prevalence ofHR- HPV infection, but it was negatively correlated with the number of high-risk HPV subtypes infection. Besides HPV 16, HPV58, 52, 33 and 31 were all closely related with cervical cancer and precancerous lesions. The prevalence of high-risk HPV had age differences, Jiangsu women over

关 键 词：高危型人乳头瘤病毒 宫颈病变 基因型 江苏 

分 类 号：R711.71[医药卫生—妇产科学] R737.33[医药卫生—临床医学]