尿8-OHdG水平与2型糖尿病患者下肢血管病变的相关性分析  

Correlation analysis of urine 8-OHdG and LVD in patients with T2DM

作　　者：易莲[1] 严胜利[1] 杨丽辉[1] 杨金萍[1] 孙亚威[1] YI Lian YAN Sheng-li YANG Li- hui YANG Jin- ping SUN Ya- wei(The First Hospital of Handan City, Handan 056002, Chin)

机构地区：[1]邯郸市第一医院,河北邯郸056002

出　　处：《现代医学》2016年第9期1191-1195,共5页Modern Medical Journal

基　　金：邯郸市科学技术研究与发展计划项目(1523108126)

摘　　要：目的:探讨2型糖尿病(T2DM)患者尿8-羟基脱氧鸟苷(8-OHdG)水平与下肢血管病变(LVD)的相关性。方法:选择T2DM患者194例,按照是否存在LVD分为T2DM组112例,T2DM+LVD组82例,同时选择健康体检者60人作为对照组,比较3组体质量指数(BMI)、腰臀比(WHR)、血压、空腹血糖(FBG)、血脂、胰岛素抵抗指数(HOMA-IR)和尿8-OHdG水平,并比较T2DM+LVD组不同病情患者HOMA-IR、尿8-OHdG水平,分析尿8-OHdG水平与LVD病情程度、HOMA-IR相关性。结果:3组糖化血红蛋白(Hb A1C)、低密度脂蛋白胆固醇(LDL-C)、HOMA-IR、尿8-OHdG间差异有统计学意义(P<0.05,P<0.01),随着病情的加重,上述指标明显升高,组间两两比较差异均有统计学意义(P<0.01);T2DM+LVD组轻度、中度、重度患者HOMA-IR、尿8-OHdG差异有统计学意义(P<0.01),随着病情的加重HOMA-IR、尿8-OHdG水平逐渐升高;经Pearson相关分析,T2DM合并LVD患者尿8-OHdG水平与HOMA-IR及LVD病变程度均呈显著正相关(r=0.412、0.538,均P<0.05),尿8-OHdG、HOMA-IR是T2DM患者发生LVD的独立危险因素。结论:尿8-OHdG水平可作为T2DM合并LVD的预测因子和病情判断的有效指标,在T2DM患者LVD的预防中应重视早期尿8-OHdG水平检测。Objective： To investigate the correlation of urine 8-hydroxyl deoxyguanosine（ 8-OHdG） and low limb vascular disease（ LVD） in patients with type 2 diabetes mellitus（ T2DM）. Methods： 194 patients with T2 DM were divided into T2 DM group（ 112 cases） and T2 DM ＋ LVD group（ 82 cases） according to the presence of LVD,and 60 healthy controls were chosen as the control group,body mass index（ BMI）,waist hip ratio（ WHR）,blood pressure,fasting blood glucose（ FBG）,blood lipid,insulin resistance index（ HOMA-IR） and urine 8-OHdG level of the three groups were compared,and HOMA-IR and urine 8-OHdG level in patients in different condition of the T2 DM ＋ LVD group were compared,the correlations between urine 8-OHdG level and the illness degree of LVD,HOMA-IR were analysed. Results： There were statistically significant differences in glycosylated hemoqlobn（ Hb A1C）,low density lipoprotein cholesterin（ LDL-C）,HOMA-IR and urine 8-OHdG in patients of the three groups（ P〈0. 05,P〈0. 01）,with the illness aggravating,the above indexes increased significantly,there were statistical significant differences in the comparison in pairs of the groups（ P〈0. 01）; The differences of HOMA-IR,urine 8-OHdG in mild,moderate and severe patients of the T2 DM ＋ LVD group were statistically significant（ P〈0. 01）,with the illness aggravating,HOMA-IR and urine 8-OHdG levels increased; By Pearson correlation analysis,urine 8-OHdG level in patients with T2 DM combined LVD was significantly and positively correlated with HOMA-IR and LVD lesion degree（ r = 0. 412,0. 538,P〈0. 05）,Urine 8-OHdG and HOMA-IR were the independent risk factors of LVD in patients with T2 DM. Conclusion： Urine 8-OHdG level can be used as the predictors and the effective indicators of evaluating the illness state in patients with T2 DM and LVD,so the detection of urine 8-OHdG level should be taken seriously in the prevention of LVD in the patients with T2 DM.

关 键 词：2型糖尿病 下肢血管病变 8-羟基脱氧鸟苷 胰岛素抵抗指数 

分 类 号：R587.1[医药卫生—内分泌] R543[医药卫生—内科学]